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International Journal of Microbiology
Volume 2014, Article ID 918143, 9 pages
http://dx.doi.org/10.1155/2014/918143
Research Article

The TIR Domain Containing Locus of Enterococcus faecalis Is Predominant among Urinary Tract Infection Isolates and Downregulates Host Inflammatory Response

1Institute of Medical Microbiology, Justus Liebig University, Schubertstraße 81, 35392 Giessen, Germany
2Iztacala Superior Studies Faculty, National Autonomous University of Mexico, Avenida de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico

Received 3 April 2014; Revised 11 June 2014; Accepted 30 June 2014; Published 24 July 2014

Academic Editor: Michael McClelland

Copyright © 2014 Thomas Daniel Kraemer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. S. Jin and J. Lee, “Structures of the toll-like receptor family and its ligand complexes,” Immunity, vol. 29, no. 2, pp. 182–191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Brikos and L. A. J. O'Neill, “Signalling of toll-like receptors,” Handbook of Experimental Pharmacology, no. 183, pp. 21–50, 2008. View at Google Scholar
  3. Y. Kim, M. M. Brinkmann, and H. L. Ploegh, “TLRs bent into shape,” Nature Immunology, vol. 8, no. 7, pp. 675–677, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Kumar, T. Kawai, and S. Akira, “Toll-like receptors and innate immunity,” Biochemical and Biophysical Research Communications, vol. 388, no. 4, pp. 621–625, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. R. M. Newman, P. Salunkhe, A. Godzik, and J. C. Reed, “Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian toll/interleukin-1 receptor family proteins,” Infection and Immunity, vol. 74, no. 1, pp. 594–601, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Cirl, A. Wieser, M. Yadav et al., “Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins,” Nature Medicine, vol. 14, no. 4, pp. 399–406, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. G. A. Snyder, C. Cirl, J. Jiang et al., “Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 17, pp. 6985–6990, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. G. K. Radhakrishnan and G. A. Splitter, “Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis,” Biochemical and Biophysical Research Communications, vol. 397, no. 1, pp. 59–63, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. K. Radhakrishnan, Q. Yu, J. S. Harms, and G. A. Splitter, “Brucella TIR domain-containing protein mimics properties of the toll-like receptor adaptor protein TIRAP,” Journal of Biological Chemistry, vol. 284, no. 15, pp. 9892–9898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. P. Salcedo, M. I. Marchesini, H. Lelouard et al., “Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1,” PLoS Pathogens, vol. 4, no. 2, article e21, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Askarian, N. M. van Sorge, M. Sangvik et al., “A staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling,” Journal of Innate Immunity, vol. 6, no. 4, pp. 485–498, 2014. View at Publisher · View at Google Scholar
  12. S. L. Chan, L. Y. Low, S. Hsu et al., “Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain,” The Journal of Biological Chemistry, vol. 284, no. 32, pp. 21386–21392, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Domann, T. Hain, R. Ghai et al., “Comparative genomic analysis for the presence of potential enterococcal virulence factors in the probiotic Enterococcus faecalis strain Symbioflor 1,” International Journal of Medical Microbiology, vol. 297, no. 7-8, pp. 533–539, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Fritzenwanker, C. Kuenne, A. Billion et al., “Complete genome sequence of the probiotic enterococcus faecalis symbioflor 1 clone DSM 16431,” Genome Announcements, vol. 1, no. 1, 2013. View at Publisher · View at Google Scholar
  15. F. Sievers, A. Wilm, D. Dineen et al., “Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega,” Molecular Systems Biology, vol. 7, article 539, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Zhang and J. Skolnick, “TM-align: a protein structure alignment algorithm based on the TM-score,” Nucleic Acids Research, vol. 33, no. 7, pp. 2302–2309, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Schäferkordt and T. Chakraborty, “Vector plasmid for insertional mutagenesis and directional cloning in Listeria spp.,” BioTechniques, vol. 19, no. 5, pp. 720–722, 724–725, 1995. View at Google Scholar · View at Scopus
  18. S. Machata, S. Tchatalbachev, W. Mohamed, L. Jänsch, T. Hain, and T. Chakraborty, “Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation,” The Journal of Immunology, vol. 181, no. 3, pp. 2028–2035, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. A. J. O'Neill, “The interleukin-1 receptor/Toll-like receptor superfamily: 10 Years of progress,” Immunological Reviews, vol. 226, no. 1, pp. 10–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. J. K. Gautam, L. D. Comeau, J. K. Krueger, and M. F. Smith Jr., “Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling,” Journal of Biological Chemistry, vol. 281, no. 40, pp. 30132–30142, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. Q. Zhang, C. M. Zmasek, X. Cai, and A. Godzik, “TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog,” Developmental and Comparative Immunology, vol. 35, no. 4, pp. 461–468, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. I. G. Sava, E. Heikens, and J. Huebner, “Pathogenesis and immunity in enterococcal infections,” Clinical Microbiology and Infection, vol. 16, no. 6, pp. 533–540, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Mathai, R. N. Jones, and M. A. Pfaller, “Epidemiology and frequency of resistance among pathogens causing urinary tract infections in 1,510 hospitalized patients: a report from the SENTRY Antimicrobial Surveillance Program (North America),” Diagnostic Microbiology and Infectious Disease, vol. 40, no. 3, pp. 129–136, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Hartl and E. Jones, Genetics, Analysis of Genes and Genomes, Jones and Bartlett, Burlington, Mass, USA, 7th edition, 2009.
  25. C. A. Arias and B. E. Murray, “The rise of the Enterococcus: beyond vancomycin resistance,” Nature Reviews Microbiology, vol. 10, no. 4, pp. 266–278, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. O. Shibolet and D. K. Podolsky, “TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction,” The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 292, no. 6, pp. G1469–G1473, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Franchimont, S. Vermeire, H. El Housni et al., “Deficient host-bacteria interactions in inflammatory bowel disease? the toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis,” Gut, vol. 53, no. 7, pp. 987–992, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Clevers, “At the crossroads of inflammation and cancer,” Cell, vol. 118, no. 6, pp. 671–674, 2004. View at Publisher · View at Google Scholar · View at Scopus