Review Article

Current Progress in the Structural and Biochemical Characterization of Proteins Involved in the Assembly of Lipopolysaccharide

Figure 1

LPS chemical structure. Chemical structures of the canonical lipid A of E. coli, the core oligosaccharide of E. coli K-12, and the E. coli O9 O-antigen (showing one repeat unit) [1]. The text for the distal glucosamine of lipid A attached to the core oligosaccharide is colored blue. The text for the residues at each end of the core oligosaccharide is colored red. The text for the ends of the O-antigen is colored green, and that for the repeat region is colored purple. In the core oligosaccharide, atom and bond coloring indicates different core structures [3]. Black indicates the conserved structure, and purple, red, and green indicate moieties present in three different variants of the K-12 core. Glucuronic acid (GlcUA, orange) may be attached to HepIII in the absence of the phosphate on HepII [4]. Dual coloring of moieties indicates their presence in both variants. Chemical structure figures were generated with ChemBioDraw Ultra 14.0.