Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity

Table 3

Infection of C57BL/6 mice with M. bovis BCG grown under laboratory and granuloma-like conditions.

Infection/condition	CFU/g^a
	3 days		2 weeks
	Lung	Spleen	Lung	Spleen
M. bovis BCG (regular lab)	1.6 ± 0.4 × 10^6	8.4 ± 0.4 × 10^4	1.4 ± 0.6 × 10^4	7.0 ± 0.5 × 10^2
M. bovis BCG (granuloma-like)	2.2 ± 0.3 × 10^6	7.6 ± 0.2 × 10^4	1.7 ± 0.7 × 10	5.1 ± 0.4 × 10

^a12 mice/group infected with 3 × 10⁶ bacteria. The significance of differences between the granuloma-like and regular lab conditions, recorded with bacterial CFU at 2 weeks of infection, was .