Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition

Figure 3

Engineered Clostridium sporogenes playing important roles as a delivery vector. In the beginning, the gene nitroreductase (PCE) is introduced into the chromosome of bacteria. Second, the engineered strains are put in specific environment to form spores. Third, the spores are injected into the lab mice infected with cancer. Forth, the spores colonize and the prodrug is transferred into the tumor cells causing tumor lysis (updated from [129]).