Research Article
Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa
Table 1
Structures of tested non-antimicrobial drugs screened for antibacterial effects on S. aureus and P. aeruginosa, MIC, and % cell viability.
| Drug | Organism | MIC (μg/ml) | % cell viability |
| Probenecid | S. aureus | — | 42.8 | | P. aeruginosa | — | 56.9 | Amodiaquine | S. aureus | — | 33 | | P. aeruginosa | — | 43.2 | 2-Amino-5-chlorobenzaxazole | S. aureus | — | 34.7 | | P. aeruginosa | — | 46 | Quercetin | S. aureus | — | 40 | | P. aeruginosa | — | 65.9 | Ibuprofen | S. aureus | — | 70.6 | | P. aeruginosa | — | 59.3 | Epicatechin | | | | | S. aureus | — | 7.1 | | P. aeruginosa | — | 49 | Ellargic acid | S. aureus | 100 | 4.9 | | P. aeruginosa | — | 36.8 | Curcumin | S. aureus | 100 | | | −2.98 | | | | P. aeruginosa | 50 | −16.6 | N–N Diacryloylpiperazine | S. aureus | — | 58 | | P. aeruginosa | — | 54 | Quinine | S. aureus | — | 13.1 | | P. aeruginosa | — | 40.3 | Ciprofloxacin | S. aureus | 0.25 | −0.8 | | P. aeruginosa | 0.5 | −1.1 |
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“–” indicates no MIC.
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