Mathematical Modelling of Glucose-Insulin System and Test of Abnormalities of Type 2 Diabetic Patients

Figure 1

Schematic representation of the model for a diabetic patient. We have three main physiological compartments, namely, heart, liver, tissues, and pancreas. The tissues compartment is introduced as one compartment that contains four additional compartments (brain, kidney, gut, and periphery, i.e., skeletal muscle and adipose tissue, vascular-lymphatic system, skin, bones, and peripheral nervous system). The direction of blood flow is represented by the arrows which connect the physiological compartments. For notational purposes, we use subscripts in order to distinguish the physiological compartments. They indicate fluid spaces within compartments.