Table of Contents
Indian Journal of Materials Science
Volume 2013, Article ID 516021, 8 pages
http://dx.doi.org/10.1155/2013/516021
Research Article

Preparation and Characterization of Poly(vinyl alcohol)-chondroitin Sulphate Hydrogel as Scaffolds for Articular Cartilage Regeneration

1Nanomedical Research Centre, ISF College of Pharmacy, VPO-Ghal Kalan, Ferozepur G.T. Road, Moga, Punjab 142001, India
2Department of Pharmacology, ISF College of Pharmacy, VPO-Ghal Kalan, Ferozepur G.T. Road, Moga, Punjab 142001, India

Received 31 July 2013; Accepted 19 September 2013

Academic Editors: A. Bhattacharyya and S. Dhara

Copyright © 2013 Shivani Nanda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was to develop PVA-CS hydrogel scaffolds using glutaraldehyde as a cross-linking agent by chemical cross-linking method in order to obtain biomimetic scaffolds for articular cartilage regeneration. The introduction of PVA enhances the mechanical and bioadhesive properties to the native tissue while chondroitin sulphate enhances the glycosaminoglycan content of extracellular matrix. The role of hydrogel as cartilage regeneration scaffold was evaluated by swelling study, porosity, rheological behaviour, in vitro degradation, and quantification of released chondroitin sulphate. In vivo results showed that cross-linked hydrogels repaired defects with no sign of inflammation as it was well anchored to tissue in the formation of new articular surface. It may be concluded that the addition of chondroitin sulphate to the PVA polymer develops a novel composite with significant applications in cartilage tissue engineering.