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International Journal of Nephrology
Volume 2010, Article ID 612126, 6 pages
Research Article

Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients

1Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China
2Kidney Transplantation Center, 117th Hospital of PLA, Hangzhou 310013, China
3Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
4Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200433, China

Received 27 December 2009; Revised 27 April 2010; Accepted 17 June 2010

Academic Editor: Jaime Uribarri

Copyright © 2010 Guang-chun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility. Results. Serum PRL, LH, and T or levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation ( ). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period. Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.