TY - JOUR A2 - Rosner, Mitchell H. AU - House, Andrew A. AU - Haapio, Mikko AU - Lentini, Paolo AU - Bobek, Ilona AU - de Cal, Massimo AU - Cruz, Dinna N. AU - Virzì, Grazia M. AU - Carraro, Rizzieri AU - Gallo, Giampiero AU - Piccinni, Pasquale AU - Ronco, Claudio PY - 2011 DA - 2010/12/02 TI - Volume Assessment in Mechanically Ventilated Critical Care Patients Using Bioimpedance Vectorial Analysis, Brain Natriuretic Peptide, and Central Venous Pressure SP - 413760 VL - 2011 AB - Purpose. Strategies for volume assessment of critically ill patients are limited, yet early goal-directed therapy improves outcomes. Central venous pressure (CVP), Bioimpedance Vectorial Analysis (BIVA), and brain natriuretic peptide (BNP) are potentially useful tools. We studied the utility of these measures, alone and in combination, to predict changing oxygenation. Methods. Thirty-four mechanically ventilated patients, 26 of whom had data beyond the first study day, were studied. Relationships were assessed between CVP, BIVA, BNP, and oxygenation index (O2I) in a cross-sectional (baseline) and longitudinal fashion using both univariate and multivariable modeling. Results. At baseline, CVP and O2I were positively correlated (R=0.39; P=.021), while CVP and BIVA were weakly correlated (R=-0.38; P=.025). The association between slopes of variables over time was negligible, with the exception of BNP, whose slope was correlated with O2I (R=0.40; P=.044). Comparing tertiles of CVP, BIVA, and BNP slopes with the slope of O2I revealed only modest agreement between BNP and O2I (kappa=0.25; P=.067). In a regression model, only BNP was significantly associated with O2I; however, this was strengthened by including CVP in the model. Conclusions. BNP seems to be a valuable noninvasive measure of volume status in critical care and should be assessed in a prospective manner. SN - 2090-214X UR - https://doi.org/10.4061/2011/413760 DO - 10.4061/2011/413760 JF - International Journal of Nephrology PB - SAGE-Hindawi Access to Research KW - ER -