International Journal of Nephrology / 2011 / Article / Tab 4

Review Article

Hepatitis C and Kidney Transplantation

Table 4

Clinical trials of monotherapy with conventional IFN or pegylated IFN in hemodialysis patients with chronic hepatitis C.

PeriodPatients numberAntiviral AgentDoses of IFN or Peg-IFNSVR

Degos et al. [132]200137IFN α3 MU three times weekly19%
Mukherjee et al. [152]20039Peg-IFN-α2b1 mcg/kg/week22%
Ozdemir et al. [133]200420IFN α3–6 MU three times weekly40%
Rivera et al. [134]200527IFN α ( )
Peg-IFN-α2a ( )
3 MU three times weekly
135 mcg/week
40%
Mahmoud et al. [61]200518IFN α3 MU three times weekly44%
Grgurevic et al. [135]200615IFN α  MU/week ( )
MU/week for 3 months, then  MU/week for another 3 months ( )
40%
Rocha et al. [136]200646IFN α3 MU three times weekly22%
Sporea et al. [153]200610Peg-IFN-α2a180 mcg/week30%
Russo et al. [151]200616Peg-IFN-α2b1 mcg/kg/week ( ), 0.5 mcg/kg/week ( )12.5%
Covic et al. [154]200678Peg-IFN-α2a135 mcg/week14%
Espinosa et al. [36]200716Peg-IFN-α2a ( )
Peg-IFN-α2b ( )
1.5 mcg/week ( ),
135 mcg/kg/week ( )
25%
Casanovas-Taltavull et al. [155]200712Peg-IFN-α2a135 mcg/week25%
Ucmak et al. [156]200812Peg-IFN-α2a135 mcg/week50%
Sikole et al. [157]200814Peg-IFN-α2a135 mcg/week41%
Liu et al. [158]200825Peg-IFN-α2a135 mcg/week48%
Ayaz et al. [159]200822Peg-IFN-α2a135 mcg/week50%
Akhan et al. [160]200812Peg-IFN-α2a135 mcg/week50%
Werner et al. [168]201022Peg-IFN-α2a ( )
Peg-IFN-α2b ( )
180 mcg/week
1.5 mcg/kg/week 1 mcg/kg/week (1 patient)
45%

IFN: interferon; MU: million units; Peg-IFN: pegylated interferon; SVR: sustained virological response.