Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome

Table 2

List of enriched biological processes and molecular functions. Given are the total number of genes assigned to a process/function, the number of genes assigned as derived from literature mining, the number of genes expected from a statistical perspective, and the significance level of enrichment.

Biological process	No. genes total	No. genes CRS	No. genes CRS expected	𝑃-value
Signal transduction	4191	135	57,67	4.55E-25
Cell communication	4365	136	60,07	6.84E-24
Cell surface receptor linked signal transduction	2235	91	30,76	3.80E-22
Immune system process	2628	97	36,16	9.70E-21
Blood circulation	210	28	2,89	5.11E-19
Regulation of biological process	59	18	0,81	1.01E-18
Regulation of vasoconstriction	59	18	0,81	1.01E-18
Molecular function	No. genes total	No. genes CRS	No. genes CRS expected	𝑃-value
Receptor binding	1233	64	16,97	2.46E-20
Protein binding	3157	103	43,44	2.71E-18
Catalytic activity	5336	128	73,43	1.44E-12
Oxidoreductase activity	703	33	9,67	1.21E-09
Binding	6751	140	92,9	3.65E-09
Kinase activity	695	28	9,56	5.18E-07