Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome

Table 3

List of enriched biological pathways. Given are the total number of genes assigned to a process/function, the number of genes assigned as derived from literature mining for CRS, the number of genes expected from a statistical perspective, and the significance level of enrichment.

Pathway	No. genes total	No. genes CRS	No. genes CRS expected	𝑃-value
Angiogenesis	191	28	2,63	4.51E-20
Endothelin signaling pathway	91	21	1,25	3.33E-19
VEGF signaling pathway	75	15	1,03	3.33E-13
Inflammation mediated by chemokine and cytokine signaling pathway	283	24	3,89	2.76E-12
PDGF signaling pathway	159	18	2,19	1.68E-11
T cell activation	102	14	1,4	2.72E-10
Apoptosis signaling pathway	123	15	1,69	3.10E-10