Table 3: List of enriched biological pathways. Given are the total number of genes assigned to a process/function, the number of genes assigned as derived from literature mining for CRS, the number of genes expected from a statistical perspective, and the significance level of enrichment.

PathwayNo. genes totalNo. genes CRSNo. genes CRS expected -value

Angiogenesis191282,634.51E-20
Endothelin signaling pathway91211,253.33E-19
VEGF signaling pathway75151,033.33E-13
Inflammation mediated by chemokine and cytokine signaling pathway283243,892.76E-12
PDGF signaling pathway159182,191.68E-11
T cell activation102141,42.72E-10
Apoptosis signaling pathway123151,693.10E-10