The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat
Figure 2
(a) The effect of fructose-feeding on the renal vascular responses to adrenergic agonists and Ang II. The vascular responses, as assessed by the reduction in renal cortical blood flow (CBF) due to adrenergic agonists or Ang II intra-arterial administration (see methods), were significantly lower in fructose-fed (the gray square) compared to control (the white square) animals. (b) The effect of streptozotocin-induced diabetes on the renal vascular responses to adrenergic agonists and renal nerve stimulation. The vascular response to adrenergic stimuli as assessed by reduction in total renal blood flow (RBF) due to renal vasoconstriction was slightly lower although significant only for noradrenaline in diabetic (the gray square) compared to nondiabetic (the white square) rats. Figures are reproduced from Abdulla et al. [16] and Armenia et al. [144] respectively. Data, mean ± SEM represent the overall mean of responses to a range of doses from each agonist. Statistical analysis was performed by unpaired t-test for comparing between two groups each time, is of fructose-fed versus control in (a) or diabetic versus nondiabetic in (b), (). NA: Noradrenaline; PE: phenylephrine; ME: methoxamine; RNS: renal nerve stimulation.
