Review Article
The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat
Table 1
The effect of different routes of fructose administration in different species over different time periods.
| Method of administration | Species |
Amount* | Length of study | Effect | Reference |
| Drinking | Mouse | 10% | 3 weeks | -Hypertension, hyperinsulinemia | [13] | | Rat | 10% | 8 weeks | -Hypertension, hypertriglyceridemia | [11] | | | | 5 weeks | -Hypertension, insulin resistance | [14] | | | | 6–19 days | -Hypertriglyceridemia | [15] | | | 20% | 8 weeks 30 days | -Hypertension, hyperglycemia, hyperinsulinemia | [16] | | | | | -Impaired glucose tolerance, dyslipidemia | [17] | | | 60% | 2 weeks | Hyperglycemia | [18] | | Hamster | 10%, 20% | 2, 4 and 6 months | Hyperglycemia, hyperinsulinemia | [19] | | guinea pigs | 10% | 6–19 days | Hypertriglyceridemia | [15] | | | 10% | 18 weeks | Hyperglycemia | [20] |
| Food | Mouse | 60% | 8 weeks | -Hypertension, impaired glucose tolerance, dyslipidemia | [21] | | Rat | 60% | 8 weeks | -Hypertension, hypertriglyceridemia | [11] | | | | 6 weeks | -Hyperinsulinemia, hypertriglyceridemia | [22] | | | 66% | 4 weeks | -Hyperinsulinemia | [23] | | | | 2 weeks | -Hypertension, hyperinsulinemia, hypertriglyceridemia | [24] | | | | 4 weeks | -Hyperglycemia | [18] | | Hamster | 60% | 2 weeks | -Hyperinsulinemia, hypertriglyceridemia | [25] | | Dog | 60% | 20–28 days | -Hypertension, insulin resistance, hyperinsulinemia, hypertriglyceridemia | [26] | | Human | 15% | 5 weeks | -Hyperinsulinemia, hyperglycemia | [27] | | | 20% | 5 weeks | -Hypertriglyceridemia | [28] |
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*Percentageis (weight/volume) for drinking form and (weight/weight) for food form.
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