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International Journal of Nephrology
Volume 2012 (2012), Article ID 146987, 11 pages
http://dx.doi.org/10.1155/2012/146987
Review Article

Urinary Markers of Glomerular Injury in Diabetic Nephropathy

1Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
2Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA

Received 21 January 2012; Accepted 20 February 2012

Academic Editor: Omran Bakoush

Copyright © 2012 Abraham Cohen-Bucay and Gautham Viswanathan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetic nephropathy, the leading cause of renal failure worldwide, affects approximately one-third of all people with diabetes. Microalbuminuria is considered the first sign and the best predictor of progression to renal failure and cardiovascular events. However, albuminuria has several limitations. Therefore, earlier, more sensitive and specific biomarkers with greater predictability are needed. The aim of this paper is to discuss the current literature on biomarkers of glomerular injury that have been implicated in diabetic kidney disease.