Transcription of the Tumor Suppressor Genes p53 and RB in Lymphocytes from Patients with Chronic Kidney Disease: Evidence of Molecular Senescence?
Table 1
Demographic data, inflammation markers, chronic health disorders, and pharmaceutical therapy of the populations included in the study.
Group
Patient data
Healthy controls
Chronic kidney disease patients
Dialysis patients
()
()
()
Age in years (mean/St. Dev.)
49.80/17.59
55.50/10.74
45.60/6.98
Sex (male/female)
8/2
6/4
8/2
GFR mL/min (mean/St. Dev.)
104.40/9.89
37.40/12.35
1.00/0.00
BMI kg/m2 (mean/St. Dev.)
27.58/4.60
26.76/2.90
25.73/3.90
Serum CRP mg/dL, value = 0.445 (mean/St. Dev./Std. error)
0.086/0.187/0.059
0.392/1.026/0.324
0.441/0.493/0.156
Serum IL-6 pg/mL, value = 0.241 (mean/St. Dev./Std. error)
3.180/1.147/0.363
5.070/3.436/1.086
5.070/3.273/1.035
Serum IL-10 pg/mL, value = 0.572 (mean/St. Dev./Std. error)
18.480/6.759/2.137
16.660/5.990/1.894
14.800/9.542/3.180
Serum TNF- pg/mL, value = 0.002 (mean/St. Dev./Std. error)
6.150/0.628/0.198
9.240/3.739/1.182
15.620/7.428/2.349
Smoking*
1
1
2
Diabetes
1
1
1
Hypertension
5
6
6
Atherosclerosis
2
1
6
Heart failure
0
0
2
ACE inhibitors
1
5
1
AT1
1
3
1
CC blockers
1
3
4
Beta blockers
2
2
4
Diuretics
0
2
3
Statins
2
1
1
NSAIDS
0
1
2
Aspirin
0
2
7
Antiplatelets
1
0
6
Phosphate binders
0
1
6
Sevelamer
0
0
6
Vitamin D
0
0
8
Erythropoietin
1
0
10
FE
0
1
8
GFR: glomerular filtration rate calculated with the Cockcroft-Gault formula; BMI: body mass index; ACE: angiotensin-converting enzyme; AT1: sartan; CC: calcium channel; NSAIDS: non steroids anti-inflammatory drugs; FE: iron supplements.
*The numbers in that section of the table and below represent a positive statement. For example one out of ten healthy persons was a smoker while two out of ten dialysis patients were prescribed with NSAIDS.
