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International Journal of Nephrology
Volume 2012, Article ID 469265, 6 pages
Review Article

Chronic Kidney Disease in Disadvantaged Populations

1Clinical and Translational Research Center, College of Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
2Office of Minority Health Research Coordination, NIDDK, National Institutes of Health, Building 2DEM, Room 902, 6707 Democracy Blvd., Bethesda, Maryland 20892, USA
3Division of Nephrology, Department of Medicine, Charles R. Drew University of Medicine and Science, Clinical Research Center Annex, 11705 Deputy Yamamoto Place, Los Angeles, California 90262, USA

Received 8 October 2011; Revised 10 January 2012; Accepted 25 January 2012

Academic Editor: Rudolph A. Rodriguez

Copyright © 2012 David Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Disadvantaged populations across the globe exhibit a disproportionate burden of chronic kidney disease (CKD) because of differences in CKD occurrence and outcomes. Although many CKD risk factors can be managed and modified to optimize clinical outcomes, the prevailing socioeconomic and cultural factors in disadvantaged populations, more often than not, militate against optimum clinical outcomes. In addition, disadvantaged populations exhibit a broader spectrum of CKD risk factors and may be genetically predisposed to an earlier onset and a more rapid progression of chronic kidney disease. A basic understanding of the vulnerabilities of the disadvantaged populations will facilitate the adaptation and adoption of the kidney disease treatment and prevention guidelines for these vulnerable populations. The purpose of this paper is to examine recent discoveries and data on CKD occurrence and outcomes in disadvantaged populations and explore strategies for the prevention and treatment of CKD in these populations based on the established guidelines.