Clinical Study

Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association

Table 1

Participant characteristics by cohort1.

CohortWest Africans (WA)African Americans (AA)Han Chinese (HC)
MenWomenMenWomenMenWomen

N 618 (41%)879 (59%)602 (39%)937 (61%)571 (52%)529 (48%)
Age (yrs)40.4 (15.7)40.7 (14.2)43.6 (13.0)43.0 (13.7)52.5 (9.8)51.3 (9.0)
Current smoker (%)49 (8%)14 (2%)368 (61%)409 (44%)200 (35%)19 (4%)
Former smoker (%)118 (19%)12 (1%)72 (12%)108 (12%)70 (12%)0 (0%)
Regular alcohol intake (%)428 (69%)468 (53%)480 (80%)650 (69%)455 (80%)105 (20%)
BMI (kg/m2)23.7 (4.2)27.0 (6.4)28.5 (7.3)31.4 (8.8)24.6 (3.3)23.4 (2.8)
Hypertension (%)204 (33%)306 (35%)247 (41%)360 (38%)266 (47%)166 (31%)
Total cholesterol (mg/dL)2169.0 (61.5)182.5 (61.0)182.0 (56.0)188.5 (52.5)187.5 (46.8)185.6 (41.4)
HDL (mg/dL)239.0 (17.0)42.0 (19.0)48.0 (20.0)54.0 (21.0)52.6 (19.7)53.5 (19.7)
Triglycerides (mg/dL)275.0 (40.0)73.0 (41.0)91.0 (61.0)81.5 (49.5)124.0 (97.4)97.4 (61.1)
Creatinine (mg/dL)1.06 (0.23)0.80 (0.20)1.04 (0.36)0.84 (0.44)0.87 (0.36)0.63 (0.16)
eGFR (mL/min/1.73 m)105.2 (26.1)109.4 (27.3)104.6 (20.9)104.4 (24.4)98.1 (13.5)103.0 (14.2)

1Shown are means (standard deviations) or N (percentages), except where indicated.
2Median (Interquartile Range) reported due to non-normality of trait.