Study ID
reference
Interventions
No. of patients Study design Outcome
Followup (incident/prevalent) (parallel/crossover) RRF PSTR UF Peritonitis Neutral pH, lactate-buffered, low-GDP versus acidic pH, lactate-buffered, high-GDP fluids Bajo et al. [30 ] Balance versus Stay-safe 33 (I) Parallel (2) — — — — 24 months Johnson et al. [44 ] Balance versus Stay-safe 185 (I) Parallel (16) ↑ ↑ ↓ ↓ 24 months Kim et al. [36 ] Balance versus Stay-safe 91 (I) Parallel (4) ↑ ↑ ↓ — 12 months Kim et al. [45 ] Balance versus Stay-safe 26 (I) Parallel (2) — — NA NA 12 months Szeto et al. [40 ] Balance versus Stay-safe 50 (I) Parallel (1) — NA — — 12 months Williams et al. [43 ] Balance versus Stay-safe 86 (P) Crossover (22) ↑ ↑ ↓ — 24 weeks Choi et al. [31 ] Balance versus Conventional (Dianeal, Stay-safe) 104 (P) Parallel (1) — — ↑ NA 12 months Haag-Weber et al. [34 ] Gambrosol Trio versus Gambrosol 69 (I + P) Parallel (5) ↑ — — — 18 months Rippe et al. [39 ] Gambrosol Trio versus Gambrosol 21 (I + P) Parallel (9) — — NA — 24 months Lai et al. [37 ] Biocompatible (Balance, Gambrosol Trio, Physioneal) versus Conventional (Dianeal, ANDY-Disc) 125 (I) Parallel (4) ↑ ↑ ↓ NA 2.3 years Fan et al. [32 ] Biocompatible (Balance or Physioneal) versus Conventional (Stay-safe or Dianeal) 118 (I) Parallel (1) — — — — 12 months Srivastava et al. [50 ] Biocompatible (Balance or Physioneal) versus Conventional (Stay-safe or Dianeal) 267 (I) Parallel (1) NA NA NA —
2.3 yearsNeutral pH, bicarbonate (±lactate)-buffered, low-GDP versus acidic pH, lactate-buffered, high-GDP fluids Fischback et al. [65 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 6 (P) Cross-over (2) NA — — NA 2 days Fusshoeller et al. [17 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 14 (P) Cross-over (1) NA NA NA NA 12 months John et al. [66 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 10 (P) Cross-over (1) NA NA — NA 2 days Pajek et al. [38 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 21 (P) Cross-over (1) — — — NA 6 months Parikova et al. [48 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 10 (P) Cross-over (1) NA — — NA 2 days Tranaeus [41 ] 25 mmol/L bicarbonate/15 mmol/L lactate PD fluid versus 40 mmol/L lactate-buffered PD fluid 106 (P) Parallel (17) — — ↑ ↓ 12 months Fang et al. [67 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate) versus Dianeal 18 (P) Cross-over (1) NA NA ↓ NA 2 days Mactier et al. [14 ] Bicarbonate/lactate (25/15 mmol/L) versus bicarbonate (38 mmol/L) versus lactate (40 mmol/L) 18 (P) Cross-over (8) NA NA NA NA 3 days Coles et al. [68 ] Bicarbonate/lactate (25/15 mmol/L) versus bicarbonate (38 mmol/L) versus lactate (40 mmol/L) 59 (P) Parallel (5) NA — NA — 2 months Feriani et al. [47 ] Bicavera (bicarbonate 34 mmol/L) versus lactate (35 mmol/L) 123 (P) Parallel (14) — NA NA — 24 weeks Haas et al. [35 ] Bicavera (bicarbonate 34 mmol/L) versus lactate (35 mmol/L) 28 (P) Cross-over (6) — ↓ — — 6 months Fernandez-Perpén et al. [33 ] Bicavera (bicarbonate 34 mmol/L) versus lactate (35 mmol/L) 31 (I) Parallel (2) — — — — 24 months Weiss et al. [42 ] Bicarbonate (bicarbonate 34 mmol/L) versus lactate (35 mmol/L) 53 (P) Cross-over (13) ↑ — — NA 6 months Glucose sparing (NEPP) versus acidic pH, lactate-buffered, high-GDP fluids Lui [46 ] Physioneal (25 mmol/L bicarbonate/15 mmol/L lactate), Extraneal (7.5% icodextrin), Nutrineal (1.1% amino acid) versus Dianeal 150 (I) Parallel (8) — ↑ — —
