Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease
Table 1
Clinical characteristics of patients with haptoglobin genotype 2-2 compared to patients with haptoglobin genotypes 1-1 and 2-1.
Haptoglobin genotypes 1-1 and 2-1
Haptoglobin genotype 2-2
()
()
Age (y)
60 ± 11
56 ± 13
ns
Women ()
18 (45%)
2 (13%)
0.03
Smoking ()
14 (35%)
4 (25%)
ns
Body mass index (kg/m²)
28 ± 5
30 ± 5
ns
Beta-blocker treatment ()
16 (42%)
7 (44%)
ns
Haemodynamic parameters
Systolic BP (mmHg)
142 ± 18
140 ± 18
ns
Diastolic BP (mmHg)
78 ± 10
80 ± 9
ns
Heart rate (beats per min)
72 ± 10
77 ± 11
ns
Laboratory parameters
Creatinine clearance (mL/min)
35 ±18
45 ± 20
ns
Haemoglobin (mmol/L)
7.6 ± 1
8.0 ± 1
ns
Hs-CRP (mg/L)
2.5 (0.3; 24.0)
6.9 (0.6; 29.7)
0.002
HRV indices
RR (ms)
853 ± 124
790 ± 113
ns
SDNN (ms)
126 ± 37
100 ± 27
0.02
SDNNindex (ms)
45 (39; 51)
39 (33; 45)
ns
SDANN (ms)
113 ± 36
90 ± 28
0.04
pNN50 (%)
5.5 (3.5; 8.8)
3.4 (1.6; 7.1)
ns
RMSSD (ms)
24 (20; 30)
22 (17; 28)
ns
Values are mean ± SD or number of patients (%), except from high-sensitive C-reactive protein and heart rate variability indices SDNNindex, pNN50, and RMSSD which are given in geometric mean and ranges. Abbreviations: BP: blood pressure, hs-CRP: high-sensitive C-reactive protein, and HRV: heart rate variability.
