Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

Table 2

Differences in SDNN, SDANN, and high-sensitive C-reactive protein between patients with haptoglobin genotype 2-2 compared to patients with haptoglobin genotypes 1-1 and 2-1.

	Difference between haptoglobin 2-2 and haptoglobins 1-1 and 2-1^† (95% CI)	𝑃 value
SDNN
Crude*	−26.2 (−48; −4)	0.02
Adjusted**	−31.7 (−53; −10)	0.005
SDANN
Crude*	−22.7 (−44; −1)	0.04
Adjusted**	−27.4 (−48; −7)	0.01
High-sensitive C-reactive protein
Crude*	2.7 (2; 5)	0.002
Adjusted***	2.7 (1; 5)	0.003

^†Difference presented as regression coefficient and 95%CI. Haptoglobin genotypes 1-1 and 2-1 are the reference level.
*Univariate linear regression analysis.
**Multivariate linear regression analysis adjusted for age, gender, heart rate, creatinine clearance, and beta-blocker treatment.
***Multivariate linear regression analysis adjusted for age, gender, body mass index, and smoking status.