Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease
Table 1
Baseline characteristics of the study sample by tertile’s category of cystatin C and serum creatinine.
Total
Cystatin C
P value
Creatinine
P value
Tertile 1
Tertile 2
Tertile 3
Tertile 1
Tertile 2
Tertile 3
Age (years)*
75 (69–82)
70 (65–78)
74 (70–80)
81 (74–83)
<0.001
75 (67–80)
76 (71–82)
74 (69–82)
0.362
Gender (female%)
95 (52)
36 (61)
32 (53)
27 (44)
0.744
32 (54)
36 (64)
17 (26)
<0.001
SBP (mm Hg)*
140 (130–150)
140 (130–150)
140 (130–150)
140 (125–150)
0.006
140 (130–150)
140 (130–150)
140 (126–160)
0.770
DBP (mm Hg)*
80 (70–80)
80 (70–80)
80 (71–89)
70 (62–80)
0.004
80 (75–80)
80 (70–80)
80 (68–80)
0.150
BMI (Kg/m2)*
29 (26–33)
28.7 (26.8–32.6)
31.4 (27.2–33.6)
27.1 (23.9–32.2)
0.946
29.6 (26.5–32.9)
30.5 (26.7–33.9)
27.9 (24.6–32.0)
0.041
Proteinuria (gr/24 h)*
0.14 (0.08–0.27)
0.14 (0.08–0.27)
0.13 (0.08–0.32)
0.15 (0.08–0.29)
0.092
0.13 (0.08–0.22)
0.13 (0.05–0.28)
0.15 (0.08–0.32)
0.318
Glucose (mg/dL)*
102 (93–128)
106 (94–129)
104 (94–140)
98 (90–120)
0.006
103 (93–122)
111 (94–143)
100 (91–115)
0.058
Serum uric acid (mg/dL)*
6.9 (5.8–8.1)
6.5 (5.7–7.4)
6.9 (5.9–7.9)
7.5 (6.1–9.8)
0.087
6.4 (5.5–7.4)
7.0 (5.9–8.4)
7.4 (6.2–9.4)
0.004
Total cholesterol (mg/dL)*
185 (154–212)
188 (165–219)
182 (158–215)
175 (148–201)
<0.001
197 (168–225)
177 (151–201)
181 (151–202)
0.026
Serum creatinine (mg/dL)*
1.5 (1.3–1.8)
1.3 (1.2–1.5)
1.6 (1.4–1.8)
1.7 (1.4–2.1)
<0.001
1.2 (1.1–1.3)
1.5 (1.4–1.6)
1.8 (1.7–2.0)
<0.001
(mL/min/1.73 m2)*
38 (33–49)
52 (42–66)
38 (34–44)
32 (28–36)
<0.001
56 (44–66)
36 (32–43)
33 (28–37)
<0.001
(mL/min/1.73 m2)*
41 (32–52)
59 (52–67)
41 (39–44)
28 (24–32)
<0.001
54 (42–66)
39 (29–48)
36 (26–42)
<0.001
Serum cystatin C (mg/dL)*
1.6 (1.3–1.9)
1.2 (1.1–1.3)
1.6 (1.5–1.7)
2.1 (1.9–2.5)
<0.001
1.3 (1.1–1.5)
1.6 (1.4–2.0)
1.8 (1.6–2.4)
<0.001
Diabetes mellitus, n (%)
70 (39)
19 (32)
25 (42)
26 (43)
0.436
19 (32)
28 (50)
23 (35)
0.113
Tobacco, n (%)
74 (41)
30 (51)
21 (35)
23 (38)
0.171
21 (36)
15 (27)
38 (58)
0.001
ACEI, n (%)
88 (49)
30 (51)
28 (47)
30 (49)
0.900
27 (46)
31 (55)
30 (46)
0.506
ARB, n (%)
47 (26)
19 (33)
15 (25)
30 (49)
0.386
16 (27)
17 (30)
14 (21)
0.533
Hypolipidemics treatment n (%)
80 (44)
19 (33)
25 (42)
25 (41)
0.481
26 (44)
24 (43)
30 (46)
0.934
Previous CV event (%)
68 (38)
17 (29)
21 (35)
30 (49)
0.070
13 (22)
27 (48)
28 (44)
0.008
SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; eGFR-EPI: estimated glomerular filtration rate according to creatinine (eGFRcreat) and according to cystatin C (eGFRcyst); n: number; CV: cardiovascular; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker. *Data expressed as median and interquartil range.
