Table of Contents Author Guidelines Submit a Manuscript
International Journal of Nephrology
Volume 2014, Article ID 143426, 8 pages
http://dx.doi.org/10.1155/2014/143426
Review Article

Anti-VEGF Cancer Therapy in Nephrology Practice

1Department of Nephrology, Pitie-Salpetriere Hospital, 75013 Paris, France
2Department of Nephrology, Monceau Park International Clinic, 75017 Paris, France

Received 24 February 2014; Accepted 11 August 2014; Published 24 August 2014

Academic Editor: Danuta Zwolinska

Copyright © 2014 Hassan Izzedine. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. F. Dvorak, “Angiogenesis: update 2005,” Journal of Thrombosis and Haemostasis, vol. 3, no. 8, pp. 1835–1842, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. V. Bhadada, B. R. Goyal, and M. M. Patel, “Angiogenic targets for potential disorders,” Fundamental and Clinical Pharmacology, vol. 25, no. 1, pp. 29–47, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Müller-Deile, K. Worthmann, M. Saleem, I. Tossidou, H. Haller, and M. Schiffer, “The balance of autocrine VEGF-A and VEGF-C determines podocyte survival,” American Journal of Physiology-Renal Physiology, vol. 297, no. 6, pp. F1656–F1667, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Izzedine, C. Massard, J. P. Spano, F. Goldwasser, D. Khayat, and J. C. Soria, “VEGF signalling inhibition-induced proteinuria: mechanisms, significance and management,” European Journal of Cancer, vol. 46, no. 2, pp. 439–448, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. K. Barakat, N. Singh, R. Lal, R. R. Verani, K. W. Finkel, and J. R. Foringer, “Interstitial nephritis secondary to bevacizumab treatment in metastatic leiomyosarcoma,” Annals of Pharmacotherapy, vol. 41, no. 4, pp. 707–710, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Eremina, M. Sood, J. Haigh et al., “Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases,” The Journal of Clinical Investigation, vol. 111, no. 5, pp. 707–716, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. B. F. Schrijvers, A. Flyvbjerg, and A. S. de Vriese, “The role of vascular endothelial growth factor (VEGF) in renal pathophysiology,” Kidney International, vol. 65, no. 6, pp. 2003–2017, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Eremina, J. A. Jefferson, J. Kowalewska et al., “VEGF inhibition and renal thrombotic microangiopathy,” The New England Journal of Medicine, vol. 358, no. 11, pp. 1129–1136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. D. C. Sane, L. Anton, and K. B. Brosnihan, “Angiogenic growth factors and hypertension,” Angiogenesis, vol. 7, no. 3, pp. 193–201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. W. J. van Heeckeren, J. Ortiz, M. M. Cooney, and S. C. Remick, “Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?” Journal of Clinical Oncology, vol. 25, no. 21, pp. 2993–2995, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. C. Soria, C. Massard, and H. Izzedine, “From theoretical synergy to clinical supra-additive toxicity,” Journal of Clinical Oncology, vol. 27, no. 9, pp. 1359–1361, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Hurwitz and S. Saini, “Bevacizumab in the treatment of metastatic colorectal cancer: safety profile and management of adverse events,” Seminars in Oncology, vol. 33, no. 10, pp. S26–S34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. F. F. Kabbinavar, J. Schulz, M. McCleod et al., “Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial,” Journal of Clinical Oncology, vol. 23, no. 16, pp. 3697–3705, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. R. J. Motzer, B. I. Rini, R. M. Bukowski et al., “Sunitinib in patients with metastatic renal cell carcinoma,” Journal of the American Medical Association, vol. 295, no. 21, pp. 2516–2524, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. G. D. Demetri, A. T. van Oosterom, M. Blackstein et al., “Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients following failure of imatinib for metastatic GIST,” Journal of Clinical Oncology, vol. 34, p. 308s, 2005, (Abstract 4000). View at Google Scholar
  16. R. C. Kane, A. T. Farrell, H. Saber et al., “Sorafenib for the treatment of advanced renal cell carcinoma,” Clinical Cancer Research, vol. 12, no. 24, pp. 7271–7278, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. C. Yang, L. Haworth, R. M. Sherry et al., “A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer,” The New England Journal of Medicine, vol. 349, no. 5, pp. 427–434, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. M. L. Maitland et al., “Blood pressure (BP) as a biomarker for sorafenib, an inhibitor of the vascular endothelial growth factor (VEGF) signalling pathway [abstract],” ASCO Meeting Abstracts, vol. 24, p. 2035, 2035. View at Google Scholar
  19. J. Drevs, P. Siegert, M. Medinger et al., “Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors,” Journal of Clinical Oncology, vol. 25, no. 21, pp. 3045–3054, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. O. Rixe, B. Billemont, and H. Izzedine, “Hypertension as a predictive factor of Sunitinib activity,” Annals of Oncology, vol. 18, no. 6, p. 1117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Bono, H. Elfving, T. Utriainen et al., “Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma,” Annals of Oncology, vol. 20, no. 2, pp. 393–394, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Ravaud and M. Sire, “Arterial hypertension and clinical benefit of sunitinib, sorafenib and bevacizumab in first and second-line treatment of metastatic renal cell cancer,” Annals of Oncology, vol. 20, no. 5, pp. 966–967, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. B. I. Rini, S. Halabi, J. E. Rosenberg et al., “Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206,” Journal of Clinical Oncology, vol. 28, no. 13, pp. 2137–2143, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Friberg, K. Kasza, E. E. Vokes, and H. L. Kindler, “Early hypertension (HTN) as a potential pharmacodynamic (PD) marker for survival in pancreatic cancer (PC) patients (pts) treated with bevacizumab (B) and gemcitabine (G),” Journal of Clinical Oncology, vol. 23, p. 16S, 2005. View at Google Scholar
  25. S. N. Holden, S. G. Eckhardt, R. Basser et al., “Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors,” Annals of Oncology, vol. 16, no. 8, pp. 1391–1397, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. B. I. Rini, J. H. Schiller, J. P. Fruehauf et al., “Association of diastolic blood pressure (dBP) 90 mmHg with overall survival (OS) in patients treated with axitinib (AG- 013736),” Journal of Clinical Oncology, vol. 26, no. 20, abstract 3543, 2008. View at Google Scholar
  27. H. Hurwitz, P. S. Douglas, J. P. Middleton et al., “Analysis of early hypertension (HTN) and clinical outcome with bevacizumab (BV),” Journal of Clinical Oncology, vol. 28, no. 15s, 2010. View at Google Scholar
  28. J. D. Hood, C. J. Meininger, M. Ziche, and H. J. Granger, “VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 274, no. 3, pp. H1054–H1058, 1998. View at Google Scholar · View at Scopus
  29. J. R. Horowitz, A. Rivard, R. van der Zee et al., “Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension: Evidence for a maintenance role in quiescent adult endothelium,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 11, pp. 2793–2800, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. C. S. Facemire, A. B. Nixon, R. Griffiths, H. Hurwitz, and T. M. Coffman, “Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression,” Hypertension, vol. 54, no. 3, pp. 652–658, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Nixon, J. Allen, E. Miller et al., “Clinical evaluation of nitric oxide responses to anti-VEGF therapy with bevacizumab,” Journal of Clinical Oncology, vol. 25, no. 18S, 2007. View at Google Scholar
  32. N. Steeghs, M. Hovens, and A. Rabelink, “VEGFr2 blockade in patients with solid tumors: mechanisms of hypertension and effects on vascular function,” Journal of Clinical Oncology, vol. 24, abstract 3037, no. 130s, 2006. View at Google Scholar
  33. B. Escudier, T. Eisen, W. M. Stadler et al., “Sorafenib in advanced clear-cell renal-cell carcinoma,” The New England Journal of Medicine, vol. 356, no. 2, pp. 125–134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. J. M. Llovet, S. Ricci, V. Mazzaferro et al., “Sorafenib in advanced hepatocellular carcinoma,” New England Journal of Medicine, vol. 359, no. 4, pp. 378–390, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. G. D. Demetri, A. T. van Oosterom, C. R. Garrett et al., “Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial,” The Lancet, vol. 368, no. 9544, pp. 1329–1338, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. R. J. Motzer, T. E. Hutson, P. Tomczak et al., “Sunitinib versus interferon alfa in metastatic renal-cell carcinoma,” The New England Journal of Medicine, vol. 356, no. 2, pp. 115–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. B. P. Schneider, M. Wang, M. Radovich et al., “Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100,” Journal of Clinical Oncology, vol. 26, no. 28, pp. 4672–4678, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Eechoute, A. A. M. van der Veldt, S. Oosting et al., “Polymorphisms in endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) predict sunitinib-induced hypertension,” Clinical Pharmacology and Therapeutics, vol. 92, no. 4, pp. 503–510, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. J. A. Allen, A. Adlakha, and P. R. Bergethon, “Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer,” Archives of Neurology, vol. 63, no. 10, pp. 1475–1478, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Govindarajan, J. Adusumilli, D. L. Baxter, A. El-Khoueiry, and S. I. Harik, “Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006,” Journal of Clinical Oncology, vol. 24, no. 28, article e48, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. A. V. Chobanian, G. L. Bakris, H. R. Black et al., “National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report,” Journal of the American Medical Association, vol. 289, pp. 2560–2572, 2003. View at Google Scholar
  42. H. Hurwitz, L. Fehrenbacher, W. Novotny et al., “Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer,” The New England Journal of Medicine, vol. 350, no. 23, pp. 2335–2342, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Miller, M. Wang, J. Gralow et al., “Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer,” The New England Journal of Medicine, vol. 357, no. 26, pp. 2666–2676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. B. J. Giantonio, P. J. Catalano, N. J. Meropol et al., “Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200,” Journal of Clinical Oncology, vol. 25, no. 12, pp. 1539–1544, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Sandler, R. Gray, M. C. Perry et al., “Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer,” The New England Journal of Medicine, vol. 355, no. 24, pp. 2542–2550, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. B. Escudier, A. Pluzanska, P. Koralewski et al., “Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial,” The Lancet, vol. 370, no. 9605, pp. 2103–2111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. Avastin, (bevacizumab) package insert, Genentech Inc., 2008.
  48. X. Zhu, S. Wu, W. L. Dahut, and C. R. Parikh, “Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis,” The American Journal of Kidney Diseases, vol. 49, no. 2, pp. 186–193, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. O. Rixe, R. M. Bukowski, M. D. Michaelson et al., “Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study,” The Lancet Oncology, vol. 8, no. 11, pp. 975–984, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Kamba, B. Y. Y. Tam, H. Hashizume et al., “VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature,” The American Journal of Physiology: Heart and Circulatory Physiology, vol. 290, no. 2, pp. H560–H576, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Izzedine, J. C. Soria, and B. Escudier, “Proteinuria and VEGF-targeted therapies: an underestimated toxicity?” Journal of Nephrology, vol. 26, no. 5, pp. 807–810, 2013. View at Google Scholar
  52. C. Frangié, C. Lefaucheur, J. Medioni, C. Jacquot, G. S. Hill, and D. Nochy, “Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma,” The Lancet Oncology, vol. 8, no. 2, pp. 177–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. D. Roncone, A. Satoskar, T. Nadasdy, J. P. Monk, and B. H. Rovin, “Proteinuria in a patient receiving anti-VEGF therapy for metastatic renal cell carcinoma,” Nature Clinical Practice Nephrology, vol. 3, no. 5, pp. 287–293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Izzedine, I. Brocheriou, G. Deray, and O. Rixe, “Thrombotic microangiopathy and anti-VEGF agents,” Nephrology Dialysis Transplantation, vol. 22, no. 5, pp. 1481–1482, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. G. Bollée, N. Patey, G. Cazajous et al., “Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib,” Nephrology Dialysis Transplantation, vol. 24, no. 2, pp. 682–685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Kapiteijn, A. Brand, J. Kroep, and H. Gelderblom, “Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome,” Annals of Oncology, vol. 18, no. 10, pp. 1745–1747, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. S. A. Levey, R. S. Bajwa, M. M. Picken, J. I. Clark, K. Barton, and D. J. Leehey, “Thrombotic microangiopathy associated with sunitinib, a VEGF inhibitor, in a patient with factor V Leiden mutation,” NDT Plus, vol. 1, no. 3, pp. 154–156, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. H. Izzedine, M. Mangier, V. Ory et al., “Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapy,” Kidney International, vol. 85, no. 2, pp. 457–470, 2014. View at Publisher · View at Google Scholar
  59. D. R. Feldman, M. S. Baum, M. S. Ginsberg et al., “Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma,” Journal of Clinical Oncology, vol. 27, no. 9, pp. 1432–1439, 2009. View at Google Scholar
  60. H. Izzedine, O. Rixe, B. Billemont, A. Baumelou, and G. Deray, “Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension,” American Journal of Kidney Diseases, vol. 50, no. 2, pp. 203–218, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. H. Izzedine, S. Ederhy, F. Goldwasser et al., “Management of hypertension in angiogenesis inhibitor-treated patients,” Annals of Oncology, vol. 20, no. 5, pp. 807–815, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. A. Pande, J. Lombardo, E. Spangenthal, and M. Javle, “Hypertension secondary to anti-angiogenic therapy: experience with bevacizumab,” Anticancer Research, vol. 27, no. 5, pp. 3465–3470, 2007. View at Google Scholar · View at Scopus
  63. M. L. Veronese, A. Mosenkis, K. T. Flaherty et al., “Mechanisms of hypertension associated with BAY 43-9006,” Journal of Clinical Oncology, vol. 24, no. 9, pp. 1363–1369, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. S. Boehm, C. Rothermundt, D. Hess, and M. Joerger, “Antiangiogenic drugs in oncology: a focus on drug safety and the elderly—a mini-review,” Gerontology, vol. 56, no. 3, pp. 303–309, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Geiger-Gritsch, B. Stollenwerk, R. Miksad, B. Guba, C. Wild, and U. Siebert, “Safety of bevacizumab in patients with advanced cancer: a meta-analysis of randomized controlled trials,” Oncologist, vol. 15, no. 11, pp. 1179–1191, 2010. View at Publisher · View at Google Scholar · View at Scopus
  66. E. S. Robinson, U. A. Matulonis, P. Ivy et al., “Rapid development of hypertension and proteinuria with cediranib, an oral vascular endothelial growth factor receptor inhibitor,” Clinical Journal of the American Society of Nephrology, vol. 5, no. 3, pp. 477–483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Hapani, D. Chu, and S. Wu, “Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis,” The Lancet Oncology, vol. 10, no. 6, pp. 559–568, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. A. P. Hall, F. Russell Westwood, and P. F. Wadsworth, “Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate,” Toxicologic Pathology, vol. 34, no. 2, pp. 131–147, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. O. Artunay, E. Yuzbasioglu, R. Rasier, A. Sengul, and H. Bahcecioglu, “Posterior reversible encephalopathy syndrome after intravitreal bevacizumab injection in patient with choroidal neovascular membrane secondary to age-related maculopathy,” Journal of Ocular Pharmacology and Therapeutics, vol. 26, no. 3, pp. 301–303, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. Q. S. Chu, “Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors,” Expert Opinion on Biological Therapy, vol. 9, no. 2, pp. 263–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. J. S. Rudge, J. Holash, D. Hylton et al., “VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 47, pp. 18363–18370, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. P. Bhargava and M. O. Robinson, “Development of second-generation VEGFR tyrosine kinase inhibitors: Current status,” Current Oncology Reports, vol. 13, no. 2, pp. 103–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. S. P. Ivy, J. Y. Wick, and B. M. Kaufman, “An overview of small-molecule inhibitors of VEGFR signaling,” Nature Reviews Clinical Oncology, vol. 6, no. 10, pp. 569–579, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. Y. Wu, Z. Zhong, J. Huber et al., “Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer,” Clinical Cancer Research, vol. 12, no. 21, pp. 6573–6584, 2006. View at Publisher · View at Google Scholar · View at Scopus