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International Journal of Nephrology
Volume 2014, Article ID 350640, 6 pages
http://dx.doi.org/10.1155/2014/350640
Research Article

High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

1Department of Paediatrics, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria
2Department of Paediatrics, Lagos University Teaching Hospital, Idi-Araba, PMB 12003, Lagos, Nigeria

Received 21 February 2014; Accepted 24 June 2014; Published 16 July 2014

Academic Editor: Tibor Nadasdy

Copyright © 2014 Taiwo Augustina Ladapo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including age, response to treatment, and renal histology were analysed. There were 108 children (median age: 5.9 years, peak: 1-2 years), 90.2% of whom had idiopathic nephrotic syndrome. Steroid sensitivity was 82.8% among children with idiopathic nephrotic syndrome but 75.9% overall. Median time to remission was 7 days. Median age was significantly lower in steroid sensitive compared with resistant patients. The predominant histologic finding in resistant cases was focal segmental glomerulosclerosis (53.3%). No cases of quartan malaria nephropathy or hepatitis B virus nephropathy were diagnosed. Overall mortality was 6.5%. In conclusion, unusually high steroid sensitivity is reported among a cohort of black children. This is likely attributable to the lower age structure of our cohort as well as possible changing epidemiology of some other childhood diseases. Surveillance of the epidemiology of childhood nephrotic syndrome and corresponding modifications in practice are therefore recommended.