Impaired Urine Dilution Capability in HIV Stable Patients

Table 2

Comparison between HIV tenofovir group (T) and HIV nontenofovir group (nT) at baseline (B) and at maximum dilution (D) (Chaimowitz’ test): eGFR, fractional excretion (FE), and plasma and urine osmolarity values—median and range.

	HIV tenofovir; baseline	HIV tenofovir; dilution	P value	HIV nontenofovir; baseline	HIV nontenofovir; dilution	P value	P value; T (B) versus nT (B); T (D) versus nT (D)
eGFR (MDRD) (mL/min/1.73 m^2)	103.9 (65–125)	103.9 (72–134)	NS	98 (79.4–139)	100 (79.4–141)	NS	NS
FE sodium (%)	0.59 (0.25–1.8)	0.78 (0.48–1.27)	NS	0.52 (0.4–1.0)	0.87 (0.36–1.56)	0.01	NS
FE potassium (%)	4.9 (3.3–11.1)	7.8 (1.18–19)	NS	6.4 (0.8–13)	13.3 (3.5–18)	0.005	0.04
FE chloride (%)	0.68 (0.47–3.7)	1.4 (1.1–1.7)	NS	0.58 (0.28–5.7)	1.6 (0.81–5.0)	NS	NS
FE phosphate (%)	14 (6–20)	15.6 (3.79–24)	NS	15.5 (3–23)	10.75 (0.6–19)	NS	NS
FE calcium (%)	0.68 (0.34–1.5)	1.4 (0.99–1.7)	0.02	0.58 (0.46–1.3)	2.0 (0.19–2.8)	0.02	0.04
FE magnesium (%)	2.05 (0.8–3)	2.7 (2.2–7.48)	NS	1.53 (0.44–4.9)	4.2 (0.45–5.0)	0.04	NS
FE urea (%)	47 (21–60)	46 (27–300)	NS	57 (20–460)	65 (44–110)	NS	NS
FE uric acid (%)	4.7 (4.1–7.9)	7.9 (6.0–10.0)	NS	4.4 (0.36–8.7)	10 (2.0–29)	NS	NS
Plasma osmolarity (mOsm/L)	282.5 (279–292)	278.5 (270–283)	0.009	285 (277–298)	278 (273–289)	0.005	NS
Urine osmolarity (mOsm/L)	418.5 (142–759)	138.5 (38–594)	0.005	659 (369–854)	92 (37–323)	0.003	NS