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International Journal of Nephrology
Volume 2014, Article ID 746497, 8 pages
http://dx.doi.org/10.1155/2014/746497
Research Article

Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians

1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, Singapore 119228
2Singapore Eye Research Institute, c/o Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751
3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Singapore 119228
4Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, 8 College Road, Singapore 169857
5Department of Laboratory Medicine, National University Hospital and National University Health System, 5 Lower Kent Ridge Road, Singapore 119074
6Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, National University of Singapore, 8 College Road, Singapore 169857
7Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, Singapore 119228

Received 14 January 2014; Accepted 11 March 2014; Published 27 April 2014

Academic Editor: Jaime Uribarri

Copyright © 2014 Boon Wee Teo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may improve eGFR accuracy. We evaluated the new CKD-EPI equations incorporating cystatin C in a population of Asian Indians in classifying CKD across body mass index, diabetes, and hypertension status. Methods. We retrieved standardized serum creatinine and serum cystatin C data from a cohort of 2877 Asian Indians aged 40–80 years from the Singapore Indian Eye Study and calculated eGFR (in mL/min/1.73 m2) with the new CKD-EPI equations and serum creatinine only equation. Results. The creatinine only equation mean eGFR (88 ± 17) was similar to using spline Log cystatin C (88 ± 22). The lowest mean eGFR (81 ± 21) was obtained with the spline Log cystatin C—age, sex, and weight equation. The creatinine only equation had the fewest participants (7.1%) with eGFR <60 and spline Log cystatin C—age, sex, and weight equation had the most (16.1%). Conclusions. Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.