Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population
Table 1
Characteristics of 119 participants by fourths of the distribution of eGFRcys.
Characteristic
Categories of eGFRcys
eGFRcys limits, mL/min/1.73 m2
>93.7
93.7–78.7
78.7–61.5
≤61.5
⋯
Number of subjects (%)
30
30
30
29
⋯
Women
18 (60.0)
22 (73.3)
12 (40.0)
16 (53.3)
0.063
Smokers
4 (13.3)
5 (16.7)
3 (10.0)
4 (13.8)
0.90
Drinking alcohol
16 (53.3)
13 (43.3)
12 (40.0)
12 (41.4)
0.73
Hypertension
8 (26.7)
11 (36.7)
16 (53.3)
18 (62.1)
0.027
Antihypertensive treatment
3 (10.0)
8 (26.7)
12 (40.0)
12 (66.6)
0.32
Cardiovascular disease
2 (6.7)
1 (3.3)
3 (10.0)
2 (6.9)
0.87
Diabetes mellitus
4 (13.3)
1 (3.3)
7 (23.3)*
8 (27.6)
0.058
Mean (SD) of characteristic
Age, years
41.3 (14.0)
52.1 (14.7)†
64.2 (13.9)†
68.9 (11.8)
<0.0001
Body mass index, kg/m2
27.6 (4.4)
29.2 (5.1)
29.1 (5.3)
29.5 (4.6)
0.44
Office blood pressure
Systolic pressure, mmHg
118.5 (15.1)
123.3 (16.6)
130.9 (21.1)
133.6 (22.0)
0.0097
Diastolic pressure, mmHg
79.3 (10.6)
78.2 (11.9)
79.8 (12.1)
81.4 (12.7)
0.79
Pulse rate, beats per minute
71.3 (7.1)
69.1 (9.9)
75.4 (8.9)*
71.0 (9.8)
0.054
Central augmentation index, %
14.7 (14.8)
19.6 (11.3)
28.7 (9.8)†
23.6 (10.9)
<0.0001
Aortic pulse wave velocity, m/s
7.6 (1.8)
8.6 (2.5)
11.1 (3.2)†
10.0 (2.9)
<0.0001
Biochemical measurements
Total cholesterol (mg/dL)
204.2 (30.2)
194.6 (28.8)
216.5 (38.6)*
225.3 (34.9)
0.004
Glucose (mg/dL)
100.0 (35.3)
96.6 (12.7)
101.8 (21.6)
101.9 (15.6)
0.88
Serum cystatin C (mg/L)
0.75 (0.15)
0.94
1.03
1.27
<0.0001
Serum creatinine, mg/dL
0.75 (0.14)
0.81 (0.15)
0.77 (0.28)
0.92 (0.23)*
0.0077
eGFRmdrd, mL/min/1.73 m2
103.2 (21.6)
92.9 (16.1)*
90.1 (24.5)
71.9 (5.4)†
<0.0001
eGFRepi, mL/min/1.73 m2
107.1 (14.2)
96.4 (12.8)†
88.6 (17.1)*
73.4 (14.1)‡
<0.0001
eGFRmix, mL/min/1.73 m2
110.4 (13.1)
90.7
78.6
61.8
<0.0001
eGFRcys, eGFRmdrd, eGFRepi, and eGFRmix indicate estimated glomerular filtration rate derived from serum cystatin C, from serum creatinine according to the IDMS-traceable Modification of Diet in Renal Disease (MDRD) Study Equation or the Chronic Kidney Disease Epidemiology Collaboration equations, or from both serum cystatin C and creatinine. Office blood pressure was the average of five consecutive readings. Hypertension was an office blood pressure of ≥140 mmHg systolic or ≥90 mmHg diastolic or use of antihypertensive drugs. Diabetes mellitus was a fasting glucose level of ≥126 mg/dL or use of antidiabetic drugs. The central augmentation index was standardised to a heart rate of 75 beats/minute. Conversion factors: creatinine from mg/dL to mol/L, multiply by 88.4; cholesterol from mg/dL to mmol/L, multiply by 0.0259. values denote the significance of the differences in prevalence or means across quartiles of eGFRcys. Significance of the difference with the adjacent lower fourth:*; †; ‡; .
