A Study to Inform the Design of a National Multicentre Randomised Controlled Trial to Evaluate If Reducing Serum Phosphate to Normal Levels Improves Clinical Outcomes including Mortality, Cardiovascular Events, Bone Pain, or Fracture in Patients on Dialysis

Table 3

Dosing schedule in the LRG.

Titration step	Renvela	Renagel	Fosrenol	Other phosphate binder (sevelamer if previously on lanthanum and vice versa)
1	2.4 g per day in divided doses	2.4 g per day in divided doses	1.5 g per day in divided doses
2 (increase if needed)	4.8 g per day in divided doses	4.8 g per day in divided doses	2.0 g per day in divided doses
3 (increase if needed)	7.2 g per day in divided doses	7.2 g per day in divided doses	2.5 g per day in divided doses
4 (increase if needed)	9.6 g per day in divided doses	9.6 g per day in divided doses	3 g per day in divided doses
6 (if needed)	Continue at 9.6 g per day	Continue at 9.6 g per day	Continue at 3 g per day	Commence on week 3 dose
7 (increase if needed)	Continue at 9.6 g per day	Continue at 9.6 g per day	Continue at 3 g per day	Commence on week 4 dose