A Study to Inform the Design of a National Multicentre Randomised Controlled Trial to Evaluate If Reducing Serum Phosphate to Normal Levels Improves Clinical Outcomes including Mortality, Cardiovascular Events, Bone Pain, or Fracture in Patients on Dialysis

Table 4

Dosing schedule in the HRG.

Titration step	Renvela	Renagel	Fosrenol
1 if serum phosphate 2.4 mmol/L	1.6 g per day in divided doses	1.6 g per day in divided doses	500 mg per day
2 if serum phosphate 2.4 mmol/L	2.4 g per day in divided doses	2.4 g per day in divided doses	1.0 g per day in divided doses
3 if serum phosphate 2.4 mmol/L	3.2 g per day in divided doses	3.2 g per day in divided doses	1.5 g per day in divided doses
4 if serum phosphate 2.4 mmol/L	4.0 g per day in divided doses	4.0 g per day in divided doses	2.0 g per day in divided doses
6 (increase if needed)	4.8 g per day in divided doses	4.8 g per day in divided doses	2.5 g per day in divided doses
7 (increase if needed)	5.6 g per day in divided doses	5.6 g per day in divided doses	3.0 g per day in divided doses