High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy

Table 2

Comparison of functional and proteinuric parameters at baseline and at the last observation in a subset of 38 IMN patients (high UpH group 11, low UpH group 27) with 5 serial measurements along 56 ± 26 months (range 24–121).

Parameter	UpH ≥ 6.5 ( = 11)		value	UpH < 6.5 ( = 27)		value
	Baseline values	Last values		Baseline values	Last values
	Mean (±SD)	Mean (±SD)		Mean (±SD)	Mean (±SD)
Follow-up (months)		57 ± 30			51 ± 25	0.57
Mean follow-up pH		6.32 ± 0.37			5.66 ± 0.43	0.0001
sCr (mg/dL)	0.89 ± 0.33	1.23 ± 1.36	0.46	1.27 ± 0.54	2.43 ± 2.13	0.001
eGFR mL/min/1.73 m^2	94 ± 32	91 ± 40	0.81	69 ± 27	51 ± 34	<0.0001
P/C ratio	2867 ± 2117	2091 ± 3122	0.37	4399 ± 3115	3881 ± 4350	0.43
FE albumin	0.106 ± 0.144	0.165 ± 0.328	0.65	0.179 ± 0.137	0.315 ± 0.454	0.35
FE IgG	0.029 ± 0.064	0.062 ± 0.163	0.97	0.059 ± 0.067	0.150 ± 0.280	0.34
FE α1m	0.195 ± 0.212	0.503 ± 1.183	0.97	0.476 ± 0.495	1.663 ± 2.300	0.01
NAG/C/eGFR	0.157 ± 0.228	0.416 ± 0.936	0.70	0.342 ± 0.328	0.791 ± 1.088	0.23
ACE-inhibitors treatment (%)		36%			59%	0.17
Steroid + cyclophosphamide treatment (%)		36%			37%	n.s.

Note: significant values are in bold.