Clinical Study

High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy

Table 3

Baseline and last observation clinical, functional, and proteinuric parameters in 29 IMN with NS patients treated with supportive therapy with UpH ≥ 6.5 ( 10) or UpH < 6.5 ( 19).

ParameterPatients with pH ≥ 6.5 ( = 10)Patients with pH < 6.5 ( = 19) value
Mean (±SD)Mean (±SD)

Baseline pH 7.00 ± 0.335.56 ± 0.47<0.0001
Follow-up pH 6.36 ± 0.435.75 ± 0.370.005
BP ≥140/90 mmHg (%)10%74%0.002
Baseline sCr (mg/dL)0.83 ± 0.121.18 ± 0.390.013
Last observation sCr (mg/dL)1.05 ± 0.403.30 ± 2.700.027
Baseline eGFR (mL/min/1.73 m2)97 ± 1969 ± 26°0.007
Last observation eGFR (mL/min/1.73 m2)78 ± 3044 ± 39°0.026
ESRD (%)0%37%0.12
Follow-up (months)86 ± 5575 ± 520.49
P/C ratio3570 ± 19964808 ± 33610.41
FE Alb0.103 ± 0.0560.201 ± 0.1500.11
FE IgG 0.013 ± 0.0110.062 ± 0.0700.07
FE α1m0.170 ± 0.1100.499 ± 0.4400.01
NAG/C/eGFR10.134 ± 0.060.434 ± 0.4000.04

Note: significant values are in bold.
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