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International Journal of Nephrology
Volume 2016, Article ID 2180765, 7 pages
http://dx.doi.org/10.1155/2016/2180765
Research Article

Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant

1Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
2Pediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil

Received 13 September 2016; Accepted 20 November 2016

Academic Editor: Laszlo Rosivall

Copyright © 2016 Livia Victorino de Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients’ blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: ; ; pulse pressure: ; ). The endocan levels were inversely correlated with the estimated glomerular filtration rate (; ). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.