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International Journal of Nephrology
Volume 2016, Article ID 2464953, 6 pages
http://dx.doi.org/10.1155/2016/2464953
Research Article

Decreased Serum 25-hydroxyvitamin D Level Causes Interventricular Septal Hypertrophy in Patients on Peritoneal Dialysis: Cardiovascular Aspects of Endogenous Vitamin D Deficiency

1Department of Internal Medicine and Nephrology, Bagcilar Education and Research Hospital, Istanbul, Turkey
2Department of Cardiology, Bagcilar Education and Research Hospital, Istanbul, Turkey
3Department of Internal Medicine, Bagcilar Education and Research Hospital, Istanbul, Turkey
4Department of Internal Medicine and Nephrology, Bakırkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey
5Department of Biochemistry, Bagcilar Education and Research Hospital, Istanbul, Turkey
6Department of Internal Medicine and Nephrology, Sevket Yılmaz Education and Research Hospital, Bursa, Turkey
7Department of Internal Medicine and Nephrology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey

Received 11 July 2016; Accepted 1 November 2016

Academic Editor: Alessandro Amore

Copyright © 2016 Bennur Esen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. In the present study, we aimed to analyze the relation of vitamin D with echocardiographic indexes in patients with end stage renal disease (ESRD) receiving renal replacement therapy (RRT). Methods. A total of 98 patients, 64 patients on hemodialysis (HD) (29F/35M, mean age 56.75 ± 18.63 years) and 34 age matched patients on peritoneal dialysis (PD) (21F/13M, mean age 58.11 ± 10.63 years), with similar duration of ESRD and RRT were enrolled into this cross-sectional study. Echocardiographic examination was performed after dialysis session at normovolemic status. Fasting blood samples were obtained before dialysis session. Results. Patients on PD and female patients in both groups had significantly lower level of 25-OH-D3 level when compared to patients on HD or male patients (p: 0.0001 and p: 0.0001). When all participants were considered, there was no significant association between 25-OH-D3 and echocardiographic parameters; however, in patients on PD, a significant negative correlation was determined between 25-OH-D3 and diastolic blood pressure, interventricular septal hypertrophy (ISH), and left ventricular mass index (LVMI) (r: −0.424, p: 0.012; r: −0.508, p: 0.004; r: 0.489, p: 0.04, resp.). Conclusion. Low serum 25-hydroxyvitamin D levels is associated with ISH and LVMI in PD patients.