The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings

Table 1

Optimal physicochemical properties for extracorporeal removal of drugs.

	Hemodialysis	Hemofiltration	Hemoperfusion
Molecular weight	<500 Da	<40 KDa	<40 KDa
Protein binding	Low (<80%)	Low	Low or high
Volume of distribution	<1 L/Kg	<1 L/Kg	<1 L/Kg
Solubility	Water	Water	Water or lipid
Endogenous clearance	<4 mL/Kg/min	<4 mL/Kg/min	<4 mL/Kg/min