Review Article
The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings
Table 3
Summary of pharmacological and clearance properties of some pharmacological
.
| | Substance | Molecular weight (daltons) | Protein binding (%) | Volume of distribution (L/kg) | Metabolism and excretion (%) | Clearance without hemodialysis (mL/min) | Clearance with hemodialysis (mL/min) |
| | Methanol | ~32 | Minimal | ~0.6–0.77 | ~95 hepatic
~2.5 respiratory
~1 renal | ~11.3 | ~125–215 |
| | Ethylene glycol | ~62 | Minimal | 0.5–0.8 | ~80 hepatic
~20 renal | Up to 27 | 145–230 |
| | Diethylene glycol | ~62 | Minimal | ~1 | 30–50 hepatic
50–70 renal | Unknown | Unknown |
| | Isopropyl alcohol | ~60 | Minimal | ~0.45–0.55 | 80 hepatic
20 renal | Unknown | ~137 (isopropyl alcohol)
~165 (acetone) |
| | Aspirin | ~180 | ~49
(~90 with therapeutic use and ~30 in overdose) | ~0.15 | ~80 hepatic
~20 renal | 0.6–25 | 3–100 |
| | Lithium | ~74 | 0 | ~0.3–1 | >95 renal | 20–40 | 70–170 |
| | Valproic acid | ~144 | ~80–90
(continuously decreases with higher valproic acid concentrations) | ~0.1–0.5 | Predominantly hepatic | 5–10 | ~50–90 |
| | Metformin | ~129 | Minimal | ~1.1 | >90 renal | ~7 | Up to 170 |
| | Dabigatran | 471 | ~35 | ~0.85 | >80 renal | Dependent on renal function | Decreases dabigatran concentration by at least 40% |
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from [5–20].
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