Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review

Table 3

Subclinical atherosclerosis assessment of the included studies based on the Manheim Consensus.

Number	Author (Year)	Tools	Angle	Anatomical site	Walls used	IMT and plaque assessment		Measurements	Quantitative measures of plaques	Measurement during end diastole	Single observer/blinded
						cIMT or IMTmax	Plaques assessed separately
1	Pawlak et al. [39]; (2004)	NR	L	CCA (B)	FW	NR	No	Mean of 2 measurements per site	No	NR	NR; NR
2	Addabbo et al. [37]; (2007)	NR	NR	CCA (B); CB (B); ICA (B)	FW	cIMT	Yes	Mean of 6 measurements per site; DCCA	Number of plaques	Yes	Single/blinded
3	Pawlak et al. [40]; (2008)	NR	L	CCA (B)	FW	cIMT	No	Mean of 2 measurements per site	No	NR	Single/blinded
4	Nagano et al. [41]; (2009)	NR	L	CCA	LW; MW	NR	NR	Mean of 6 measurements of CCA	No	Yes	Single/blinded
5	Coll et al. [38]; (2010)	SA	L	CCA (B); CB (B); ICA (B)	FW	cIMT	Yes	NR	No	Manheim; Consensus	NR; Blinded
6	Sánchez-Escuredo et al. [36]; (2010)	NR	NR	CCA (B); CB (B); ICA (B)	FW	cIMT	If IMT > 1,2 mm	Mean of 6 measurements per site	No	Yes	Single/NR
7	Belal et al. [42]; (2014)	A	L	CCA (B)	FW	cIMT	Yes	Maximum of 2 measurements per site	No	NR	NR; NR
8	Weber et al. [35]; (2014)	—	—	—	—	—	—	—	—	—	—
9	Issac et al. [43]; (2014)	NR	L, T	NR	NR	NR	No	IMT (B), CSA (B)	No	NR	NR; NR

NR: not reported.
A: automated, SA: semiautomated.
L: longitudinal, T: transverse, and CS: cross-sectional.
CCA: common carotid artery, CB: carotid bulb, ICA: internal carotid artery, and B: bilateral.
FW: far wall, NW: near wall, LW: lateral wall, and MW: medial wall.
CSA: cross-sectional area, DCCA: internal diameter of the common carotid artery.