High Serum Alkaline Phosphatase, Hypercalcaemia, Race, and Mortality in South African Maintenance Haemodialysis Patients
Table 1
Comparisons of baseline characteristics between patients in high TAP and low TAP groups.
Characteristic
All ()
TAP ≤ 112 ()
TAP > 112 ()
value
Age (years)
0.008
Female, (%)
76 (35.7%)
35 (35.7%)
41 (35.7%)
0.25
Diabetes, (%)
56 (26.3%)
27 (27.6%)
29 (25.2%)
0.76
Weight (Kg)
0.53
BMI (Kg/m2)
0.83
Dialysis vintage (months)
24 (12–48)
36 (12–60)
36 (12–48)
0.55
Systolic Bp (mmHg)
0.38
Diastolic Bp (mmHg)
0.86
Haemoglobin (g/dL)
0.10
Potassium (mmol/L)
0.55
Calcium (mmol/L)
0.58
Corrected calcium (mmol/L)
0.42
iPTH (pg/mL)
307 (148–656)
246 (137–527)
325 (152–693)
0.09
Phosphate (mmol/L)
0.07
25-OH vitamin D (ng/mL)
0.83
Alkaline phosphatase (U/L)
112 (74–163)
74 (62–96)
163 (130–223)
<0.001
Albumin (g/L)
0.98
Type of vascular access
Arteriovenous fistula
129 (60.6%)
65 (66.3%)
64 (55.7%)
0.23
Graft
39 (18.3%)
23 (23.5%)
26 (22.6%)
0.88
Catheter
45 (21.1%)
21 (21.4%)
24 (20.9%)
0.97
Alanine transaminase (U/L)
0.20
Kt/V
0.72
n PCR (g/kg/day)
0.56
T. cholesterol (mmol/L)
0.14
Medications
Calcium carbonate, (%)
163 (76.5%)
77 (78.6%)
86 (74.7%)
0.74
Alfacalcidol, (%)
137 (64.3%)
61 (62.2%)
76 (66.1%)
0.55
ESA (%)
198 (93.0%)
94 (95.9)
104 (90.4%)
0.50
ESA dose (U/week)
0.53
Continuous variables are presented as means ± standard deviations or median (interquartile range) and categorical data as frequencies (percentages), BP = blood pressure, i PTH = intact parathyroid hormone, TAP = total alkaline phosphatase, ESA = erythropoietin stimulating agent, n PCR = normalized protein catabolic rate, and BMI = body mass index.
