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International Journal of Nephrology
Volume 2017 (2017), Article ID 3756857, 13 pages
https://doi.org/10.1155/2017/3756857
Review Article

Focused Real-Time Ultrasonography for Nephrologists

Division of Nephrology, Department of Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence should be addressed to Elaine M. Kaptein; ude.csu@nietpake

Received 1 August 2016; Revised 9 October 2016; Accepted 1 November 2016; Published 2 February 2017

Academic Editor: Anil K. Agarwal

Copyright © 2017 Matthew J. Kaptein and Elaine M. Kaptein. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Montoya, S. P. Stawicki, D. C. Evans et al., “From FAST to E-FAST: an overview of the evolution of ultrasound-based traumatic injury assessment,” European Journal of Trauma and Emergency Surgery, vol. 42, no. 2, pp. 119–126, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Inaba, K. Chouliaras, S. Zakaluzny et al., “FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation,” Annals of Surgery, vol. 262, no. 3, pp. 512–518, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Seif, P. Perera, T. Mailhot, D. Riley, and D. Mandavia, “Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol,” Critical Care Research and Practice, vol. 2012, Article ID 503254, 14 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Perera, T. Mailhot, D. Riley, and D. Mandavia, “The RUSH exam: rapid ultrasound in shock in the evaluation of the critically lll,” Emergency Medicine Clinics of North America, vol. 28, no. 1, pp. 29–56, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Bagheri-Hariri, M. Yekesadat, S. Farahmand et al., “The impact of using RUSH protocol for diagnosing the type of unknown shock in the emergency department,” Emergency Radiology, vol. 22, no. 5, pp. 517–520, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. M. R. Ghane, M. H. Gharib, A. Ebrahimi et al., “Accuracy of rapid ultrasound in shock (RUSH) exam for diagnosis of shock in critically Ill patients,” Trauma Monthly, vol. 20, no. 1, Article ID e20095, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. A. E. Jones, V. S. Tayal, D. M. Sullivan, and J. A. Kline, “Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients,” Critical Care Medicine, vol. 32, no. 8, pp. 1703–1708, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. S. A. Haydar, E. T. Moore, G. L. Higgins III, C. B. Irish, W. B. Owens, and T. D. Strout, “Effect of bedside ultrasonography on the certainty of physician clinical decisionmaking for septic patients in the emergency department,” Annals of Emergency Medicine, vol. 60, no. 3, pp. 346–358.e4, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. H. D. Kanji, J. McCallum, D. Sirounis, R. MacRedmond, R. Moss, and J. H. Boyd, “Limited echocardiography-guided therapy in subacute shock is associated with change in management and improved outcomes,” Journal of Critical Care, vol. 29, no. 5, pp. 700–705, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. W. C. O'Neill, “Renal relevant radiology: use of ultrasound in kidney disease and nephrology procedures,” Clinical Journal of the American Society of Nephrology, vol. 9, no. 2, pp. 373–381, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. E. C. Cheriex, K. M. L. Leunissen, J. H. A. Janssen, J. M. V. Mooy, and J. P. Van Hooff, “Echography of the inferior vena cava is a simple and reliable tool for estimation of ‘dry weight’ in haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 4, no. 6, pp. 563–568, 1989. View at Google Scholar · View at Scopus
  12. T. Kusaba, K. Yamaguchi, and H. Oda, “Echography of the inferior vena cava for estimating fluid removal from patients undergoing hemodialysis,” Nihon Jinzo Gakkai Shi, vol. 38, no. 3, pp. 119–23, 1996. View at Google Scholar
  13. J. M. Brennan, A. Ronan, S. Goonewardena et al., “Handcarried ultrasound measurement of the inferior vena cava for assessment of intravascular volume status in the outpatient hemodialysis clinic,” Clinical journal of the American Society of Nephrology : CJASN, vol. 1, no. 4, pp. 749–753, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Mandelbaum and E. Ritz, “Vena cava diameter measurement for estimation of dry weight in haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 11, supplement 2, pp. 24–27, 1996. View at Google Scholar · View at Scopus
  15. I. Krause, E. Birk, M. Davidovits et al., “Inferior vena cava diameter: a useful method for estimation of fluid status in children on haemodialysis,” Nephrology Dialysis Transplantation, vol. 16, no. 6, pp. 1203–1206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Hirayama, Y. Ando, Y. Sudo, and Y. Asano, “Improvement of cardiac function by dry weight optimization based on interdialysis inferior vena caval diameter,” ASAIO Journal, vol. 48, no. 3, pp. 320–325, 2002. View at Google Scholar
  17. Y. Beaulieu, “Bedside echocardiography in the assessment of the critically ill,” Critical Care Medicine, vol. 35, no. 5, supplement, pp. S235–S249, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Seif, T. Mailhot, P. Perera, and D. Mandavia, “Caval sonography in shock: a noninvasive method for evaluating intravascular volume in critically ill patients,” Journal of Ultrasound in Medicine, vol. 31, no. 12, pp. 1885–1890, 2012. View at Google Scholar · View at Scopus
  19. A. Laborda, S. Sierre, M. Malvè et al., “Influence of breathing movements and Valsalva maneuver on vena caval dynamics,” World Journal of Radiology, vol. 6, no. 10, pp. 833–839, 2014. View at Publisher · View at Google Scholar
  20. N. L. Panebianco, F. Shofer, A. Cheng, J. Fischer, K. Cody, and A. J. Dean, “The effect of supine versus upright patient positioning on inferior vena cava metrics,” The American Journal of Emergency Medicine, vol. 32, no. 11, pp. 1326–1329, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Kalantari, J. N. Chang, C. Ronco, and M. H. Rosner, “Assessment of intravascular volume status and volume responsiveness in critically ill patients,” Kidney International, vol. 83, no. 6, pp. 1017–1028, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Gignon, C. Roger, S. Bastide et al., “Influence of diaphragmatic motion on inferior vena cava diameter respiratory variations in healthy volunteers,” Anesthesiology, vol. 124, no. 6, pp. 1338–1346, 2016. View at Google Scholar
  23. F. M. Abu-Zidan, “Optimizing the value of measuring inferior vena cava diameter in shocked patients,” World Journal of Critical Care Medicine, vol. 5, no. 1, pp. 7–11, 2016. View at Publisher · View at Google Scholar
  24. T. Saul, R. E. Lewiss, A. Langsfeld, M. S. Radeos, and M. Del Rios, “Inter-rater reliability of sonographic measurements of the inferior vena cava,” Journal of Emergency Medicine, vol. 42, no. 5, pp. 600–605, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Kent, D. P. Bahner, C. T. Boulger et al., “Sonographic evaluation of intravascular volume status in the surgical intensive care unit: a prospective comparison of subclavian vein and inferior vena cava collapsibility index,” Journal of Surgical Research, vol. 184, no. 1, pp. 561–566, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Killu, S. A. Dulchavsky, and V. Coba, The ICU Ultrasound Pocket Book, 2010.
  27. P. Perera, R. Milhot, and D. Mandavia, “Rapid ultrasound in SHock: the RUSH protocol,” in Emergency Medicine: Emergency Ultrasound, pp. 18–21, 2010. View at Google Scholar
  28. R. Beigel, B. Cercek, H. Luo, and R. J. Siegel, “Noninvasive evaluation of right atrial pressure,” Journal of the American Society of Echocardiography, vol. 26, no. 9, pp. 1033–1042, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Barbier, Y. Loubières, C. Schmit et al., “Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients,” Intensive Care Medicine, vol. 30, no. 9, pp. 1740–1746, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. B. J. Kircher, R. B. Himelman, and N. B. Schiller, “Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava,” The American Journal of Cardiology, vol. 66, no. 4, pp. 493–496, 1990. View at Publisher · View at Google Scholar · View at Scopus
  31. F. L. L. Moreno, A. D. Hagan, J. R. Holmen, T. A. Pryor, R. D. Strickland, and C. H. Castle, “Evaluation of size and dynamics of the inferior vena cava as an index of right-sided cardiac function,” The American Journal of Cardiology, vol. 53, no. 4, pp. 579–585, 1984. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Nakao, P. C. Come, R. G. McKay, and B. J. Ransil, “Effects of positional changes on inferior vena caval size and dynamics and correlations with right-sided cardiac pressure,” The American Journal of Cardiology, vol. 59, no. 1, pp. 125–132, 1987. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Capomolla, O. Febo, A. Caporotondi et al., “Non-invasive estimation of right atrial pressure by combined doppler echocardiographic measurements of the inferior vena cava in patients with congestive heart failure,” Italian Heart Journal, vol. 1, no. 10, pp. 684–690, 2000. View at Google Scholar · View at Scopus
  34. K. L. Anderson, K. Y. Jenq, J. M. Fields, N. L. Panebianco, and A. J. Dean, “Diagnosing heart failure among acutely dyspneic patients with cardiac, inferior vena cava, and lung ultrasonography,” The American Journal of Emergency Medicine, vol. 31, no. 8, pp. 1208–1214, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. L. G. Rudski, W. W. Lai, J. Afilalo et al., “Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American society of echocardiography. Endorsed by the European association of echocardiography, a registered branch of the European Society of cardiology, and the Canadian society of echocardiography,” Journal of the American Society of Echocardiography, vol. 23, no. 7, pp. 685–713, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. R. H. Wachsberg, “Narrowing of the upper abdominal inferior vena cava in patients with elevated intraabdominal pressure: sonographic observations,” Journal of Ultrasound in Medicine, vol. 19, no. 3, pp. 217–222, 2000. View at Google Scholar · View at Scopus
  37. D. J. Blehar, D. Resop, B. Chin, M. Dayno, and R. Gaspari, “Inferior vena cava displacement during respirophasic ultrasound imaging,” Critical Ultrasound Journal, vol. 4, no. 1, p. 18, 2012. View at Publisher · View at Google Scholar
  38. J. A. Goldstein, “Pathophysiology and management of right heart ischemia,” Journal of the American College of Cardiology, vol. 40, no. 5, pp. 841–853, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Jellinek, H. Krenn, W. Oczenski, F. Veit, S. Schwarz, and R. D. Fitzgerald, “Influence of positive airway pressure on the pressure gradient for venous return in humans,” Journal of Applied Physiology, vol. 88, no. 3, pp. 926–932, 2000. View at Google Scholar · View at Scopus
  40. B. J. Kimura, R. Dalugdugan, G. W. Gilcrease, J. N. Phan, B. K. Showalter, and T. Wolfson, “The effect of breathing manner on inferior vena caval diameter,” European Journal of Echocardiography, vol. 12, no. 2, pp. 120–123, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Bentzer, D. E. Griesdale, J. Boyd, K. MacLean, D. Sirounis, and N. T. Ayas, “Will this hemodynamically unstable patient respond to a bolus of intravenous fluids?” JAMA, vol. 316, no. 12, pp. 1298–1309, 2016. View at Publisher · View at Google Scholar
  42. P. E. Marik, “Techniques for assessment of intravascular volume in critically ill patients,” Journal of Intensive Care Medicine, vol. 24, no. 5, pp. 329–337, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Osman, C. Ridel, P. Ray et al., “Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge,” Critical Care Medicine, vol. 35, no. 1, pp. 64–68, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Magder, G. Georgiadis, and T. Cheong, “Respiratory variations in right atrial pressure predict the response to fluid challenge,” Journal of Critical Care, vol. 7, no. 2, pp. 76–85, 1992. View at Publisher · View at Google Scholar · View at Scopus
  45. M. J. Kaptein, J. S. Kaptein, and E. M. Kaptein, Assessing Intravascular Volume Using Inferior Vena Cava Ultrasound in ICU Patients with Renal Failure, Poster at the American Society of Nephrology Meeting, Philadelphia, Pa, USA, 2014.
  46. J. M. Brennan, J. E. Blair, S. Goonewardena et al., “A comparison by medicine residents of physical examination versus hand-carried ultrasound for estimation of right atrial pressure,” American Journal of Cardiology, vol. 99, no. 11, pp. 1614–1616, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. P. E. Marik, “Noninvasive cardiac output monitors: a state-of the-art review,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 27, no. 1, pp. 121–134, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. P. E. Marik, R. Cavallazzi, T. Vasu, and A. Hirani, “Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature,” Critical Care Medicine, vol. 37, no. 9, pp. 2642–2647, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. X. Yang and B. Du, “Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis,” Critical Care, vol. 18, no. 6, article 650, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. P. E. Marik, A. Levitov, A. Young, and L. Andrews, “The use of bioreactance and carotid doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients,” Chest, vol. 143, no. 2, pp. 364–370, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Bowra, V. Uwagboe, A. Goudie, C. Reid, and M. Gillett, “Interrater agreement between expert and novice in measuring inferior vena cava diameter and collapsibility index,” Emergency Medicine Australasia, vol. 27, no. 4, pp. 295–299, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. C. Ronco, M. Kaushik, R. Valle, N. Aspromonte, and W. F. Peacock, “Diagnosis and management of fluid overload in heart failure and cardio-renal syndrome: the ‘5B’ approach,” Seminars in Nephrology, vol. 32, no. 1, pp. 129–141, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. P. E. Marik, “Fluid responsiveness and the six guiding principles of fluid resuscitation,” Critical Care Medicine, vol. 44, no. 10, pp. 1920–1922, 2015. View at Publisher · View at Google Scholar · View at Scopus
  54. S. McGee, W. B. Abernethy, and D. L. Simel, “The rational clinical examination. Is this patient hypovolemic?” JAMA, vol. 281, no. 11, pp. 1022–1029, 1999. View at Publisher · View at Google Scholar · View at Scopus
  55. T. Tuy and W. F. Peacock, “Fluid overload assessment and management in heart failure patients,” Seminars in Nephrology, vol. 32, no. 1, pp. 112–120, 2012. View at Publisher · View at Google Scholar · View at Scopus
  56. M. L. N. G. Malbrain, P. E. Marik, I. Witters et al., “Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice,” Anaesthesiology Intensive Therapy, vol. 46, no. 5, pp. 361–380, 2014. View at Publisher · View at Google Scholar · View at Scopus
  57. E. M. Kaptein, D. Sreeramoju, J. M. Kaptein, and M. J. Kaptein, “A systematic literature search and review of sodium concentrations of body fluids,” Clinical Nephrology, vol. 86, no. 10, pp. 203–228, 2016. View at Publisher · View at Google Scholar
  58. J. M. Testani, M. A. Brisco, R. D. Kociol et al., “Substantial discrepancy between fluid and weight loss during acute decompensated heart failure treatment,” American Journal of Medicine, vol. 128, no. 7, article no. e4, pp. 776–783, 2015. View at Publisher · View at Google Scholar · View at Scopus
  59. W. Frank Peacock and K. M. Soto, “Current technique of fluid status assessment,” Congestive Heart Failure, vol. 16, supplement 1, pp. S45–S51, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. C. W. C. Lee, P. D. Kory, and R. T. Arntfield, “Development of a fluid resuscitation protocol using inferior vena cava and lung ultrasound,” Journal of Critical Care, vol. 31, no. 1, pp. 96–100, 2016. View at Publisher · View at Google Scholar · View at Scopus
  61. J. G. Wilson and K. E. Breyer, “Critical care ultrasound: a review for practicing nephrologists,” Advances in Chronic Kidney Disease, vol. 23, no. 3, pp. 141–145, 2016. View at Publisher · View at Google Scholar
  62. D. A. Lichtenstein, S. Van Hooland, P. Elbers, and M. L. N. G. Malbrain, “Ten good reasons to practice ultrasound in critical care,” Anaesthesiology Intensive Therapy, vol. 46, no. 5, pp. 323–335, 2014. View at Publisher · View at Google Scholar · View at Scopus
  63. X.-T. Wang, D.-W. Liu, H.-M. Zhang, and W.-Z. Chai, “Integrated cardiopulmonary sonography: a useful tool for assessment of acute pulmonary edema in the intensive care unit,” Journal of Ultrasound in Medicine, vol. 33, no. 7, pp. 1231–1239, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. F. Michard and J.-L. Teboul, “Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence,” Chest, vol. 121, no. 6, pp. 2000–2008, 2002. View at Publisher · View at Google Scholar · View at Scopus
  65. F. Michard, S. Boussat, D. Chemla et al., “Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure,” American Journal of Respiratory and Critical Care Medicine, vol. 162, no. 1, pp. 134–138, 2000. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Garg and W. H. Fissell, “Intradialytic hypotension: a case for going slow and looking carefully,” Nephrology Dialysis Transplantation, vol. 28, no. 2, pp. 247–249, 2013. View at Publisher · View at Google Scholar · View at Scopus
  67. D. du Cheyron, N. Terzi, A. Seguin et al., “Use of online blood volume and blood temperature monitoring during haemodialysis in critically ill patients with acute kidney injury: a single-centre randomized controlled trial,” Nephrology Dialysis Transplantation, vol. 28, no. 2, pp. 430–437, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. T. A. Tanguay, L. Jensen, and C. Johnston, “Predicting episodes of hypotension by continuous blood volume monitoring among critically ill patients in acute renal failure on intermittent hemodialysis,” Dynamics, vol. 18, no. 3, pp. 19–24, 2007. View at Google Scholar · View at Scopus
  69. J. J. Dasselaar, R. M. Huisman, P. E. De Jong, and C. F. M. Franssen, “Relative blood volume measurements during hemodialysis: comparisons between three noninvasive devices,” Hemodialysis International, vol. 11, no. 4, pp. 448–455, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. P. E. Marik, M. Baram, and B. Vahid, “Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares,” Chest, vol. 134, no. 1, pp. 172–178, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. R. Moretti and B. Pizzi, “Inferior vena cava distensibility as a predictor of fluid responsiveness in patients with subarachnoid hemorrhage,” Neurocritical Care, vol. 13, no. 1, pp. 3–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  72. E. Machare-Delgado, M. Decaro, and P. E. Marik, “Inferior vena cava variation compared to pulse contour analysis as predictors of fluid responsiveness: a prospective cohort study,” Journal of Intensive Care Medicine, vol. 26, no. 2, pp. 116–124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. J. B. Miller, A. Sen, S. R. Strote et al., “Inferior vena cava assessment in the bedside diagnosis of acute heart failure,” American Journal of Emergency Medicine, vol. 30, no. 5, pp. 778–783, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. D. J. Blehar, E. Dickman, and R. Gaspari, “Identification of congestive heart failure via respiratory variation of inferior vena cava diameter,” The American Journal of Emergency Medicine, vol. 27, no. 1, pp. 71–75, 2009. View at Publisher · View at Google Scholar · View at Scopus
  75. G. Marenzi, G. Lauri, M. Grazi, E. Assanelli, J. Campodonico, and P. Agostoni, “Circulatory response to fluid overload removal by extracorporeal ultrafiltration in refractory congestive heart failure,” Journal of the American College of Cardiology, vol. 38, no. 4, pp. 963–968, 2001. View at Publisher · View at Google Scholar · View at Scopus
  76. G. Via, G. Tavazzi, and S. Price, “Ten situations where inferior vena cava ultrasound may fail to accurately predict fluid responsiveness: a physiologically based point of view,” Intensive Care Medicine, vol. 42, no. 7, pp. 1164–1167, 2016. View at Publisher · View at Google Scholar
  77. A. J. Weekes, H. M. Tassone, A. Babcock et al., “Comparison of serial qualitative and quantitative assessments of caval index and left ventricular systolic function during early fluid resuscitation of hypotensive emergency department patients,” Academic Emergency Medicine, vol. 18, no. 9, pp. 912–921, 2011. View at Publisher · View at Google Scholar · View at Scopus
  78. H. Hvarness, B. Skjoldbye, and H. Jakobsen, “Urinary bladder volume measurements: comparison of three ultrasound calculation methods,” Scandinavian Journal of Urology and Nephrology, vol. 36, no. 3, pp. 177–181, 2002. View at Publisher · View at Google Scholar · View at Scopus
  79. “Portable bladder ultrasound: an evidence-based analysis,” Ontario Health Technology Assessment Series, vol. 6, no. 11, pp. 1–51, 2006.
  80. S. Faubel, N. U. Patel, M. E. Lockhart, and M. A. Cadnapaphornchai, “Renal relevant radiology: use of ultrasonography in patients with AKI,” Clinical Journal of the American Society of Nephrology, vol. 9, no. 2, pp. 382–394, 2014. View at Publisher · View at Google Scholar · View at Scopus