TY - JOUR
A2 - Nadasdy, Tibor
AU - Sriskandarajah, Sanjeevan
AU - Bostad, Leif
AU - Myklebust, Tor Åge
AU - Møller, Bjørn
AU - Skrede, Steinar
AU - Bjørneklett, Rune
PY - 2017
DA - 2017/12/18
TI - Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
SP - 6013038
VL - 2017
AB - Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols. Methods. Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA) serology were included. Standardised incidence ratios (SIRs) were calculated to compare the study cohort with the general population. Results. The study cohort included 419 patients. During 3010 person-years, cancer developed in 41 patients (9.79%); the expected number of cancer cases was 37.5 (8.95%). The cohort had SIRs as follows: 1.09, all cancer types (95% CI, 0.81 to 1.49); 0.96, all types except nonmelanoma skin cancer (95% CI, 0.69 to 1.34); 3.40, nonmelanoma skin cancer (95% CI, 1.62 to 7.14); 3.52, hematologic cancer (95% CI, 1.32 to 9.37); 2.12, posttransplant cancer (95% CI, 1.01 to 4.44); and 1.53, during the 1–5-year follow-up after diagnosis (95% CI, 1.01 to 2.32). Conclusions. Cancer risk did not increase significantly in this cohort with ANCA-associated glomerulonephritis. However, increased risk of nonmelanoma skin cancer, posttransplant cancer, and hematologic cancer indicates an association between immunosuppression and malignancy.
SN - 2090-214X
UR - https://doi.org/10.1155/2017/6013038
DO - 10.1155/2017/6013038
JF - International Journal of Nephrology
PB - Hindawi
KW -
ER -