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International Journal of Nephrology
Volume 2017 (2017), Article ID 8210641, 5 pages
https://doi.org/10.1155/2017/8210641
Research Article

Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls

1Sanford Children’s Hospital, Sioux Falls, SD 57117, USA
2University of Tennessee Health Sciences Center, Memphis, TN 38013, USA
3Children’s Foundation Research Institute, Memphis, TN 38013, USA
4University of Alabama at Birmingham, Birmingham, AL 35294, USA

Correspondence should be addressed to Robert J. Wyatt

Received 21 March 2017; Revised 19 October 2017; Accepted 29 October 2017; Published 26 November 2017

Academic Editor: Laszlo Rosivall

Copyright © 2017 John T. Sanders et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Follow-up measurements were scheduled 6 and/or 12 months later. Analysis of variance and regression models for repeated measures were used to estimate group and time effects. Serum Gd-IgA1 level was higher in initial samples for IgAN patients compared to those of healthy children . Serum Gd-IgA1 levels did not change over time for healthy controls but increased for IgAN patients . Serum Gd-IgA1 level was elevated for 9 children with IgAN at study entry and remained elevated. Two of the 4 IgAN patients with initially normal Gd-IgA1 levels had a subsequent elevated level. The persistent elevation of the serum Gd-IgA1 level in children with IgAN enhances its utility as a potential diagnostic test for IgAN.