Table 4: Association of eGFR category and cardiovascular mortality.

Estimating equation category, mL/min/1.73 m2Age adjusted incidence rate per 1,000 person years (95% CI) Hazard ratio (95% confidence interval)
Unadjusted (site only)Base modelMV modelFinal model

BIS1
 ≥7545.7 (0.8, 90.6)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60 to <7516.5 (11.7, 21.3)0.8 (0.5, 1.2)0.7 (0.4, 1.1)0.8 (0.5, 1.2)0.8 (0.5, 1.2)
 45 to <6018.7 (14.6, 22.8)1.3 (0.8, 2.0)0.9 (0.6, 1.3)0.9 (0.6, 1.4)0.9 (0.6, 1.3)
 <4538.4 (22.9, 53.9)3.4 (2.2, 5.5)1.8 (1.1, 2.9)1.6 (0.9, 2.6)1.4 (0.9, 2.4)
p-trend<0.0010.0050.0360.099
CKD-
 ≥7519.1 (14.7, 23.4)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60 to <7519.1 (14.4, 23.8)1.4 (1.1, 2.0)1.1 (0.8, 1.6)1.1 (0.8, 1.5)1.0 (0.7, 1.4)
 45 to <6020.3 (13.0, 27.6)1.6 (1.1, 2.4)1.2 (0.8, 1.7)1.0 (0.7, 1.5)1.0 (0.7, 1.5)
 <4539.7 (21.9, 57.5)4.1 (2.7, 6.1)2.6 (1.7, 4.0)2.1 (1.3, 3.2)1.8 (1.2, 2.8)
p-trend<0.001<0.0010.0160.043
BIS2
 ≥7519.4 (9.6, 29.2)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60 to <7516.4 (12.1, 20.8)0.9 (0.5, 1.5)0.8 (0.5, 1.4)0.9 (0.5, 1.5)0.8 (0.5, 1.4)
 45 to <6019.8 (15.6, 23.9)1.6 (0.9, 2.6)1.1 (0.7, 1.8)1.1 (0.7, 1.9)1.1 (0.6, 1.8)
 <4537.5 (25.5, 49.6)3.7 (2.2, 6.3)2.2 (1.3, 3.8)1.9 (1.1, 3.4)1.7 (0.9, 3.0)
p-trend<0.001<0.0010.0010.006
CKD-
 ≥7517.5 (12.4, 22.6)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60 to <7517.8 (13.6, 21.9)1.3 (0.9, 1.9)1.1 (0.8, 1.6)1.1 (0.8, 1.6)1.1 (0.8, 1.6)
 45 to <6021.5 (15.8, 27.3)2.2 (1.5, 3.2)1.5 (1.0, 2.2)1.4 (0.9, 2.0)1.3 (0.9, 1.9)
 <4548.3 (21.4, 75.2)3.9 (2.6, 5.9)2.5 (1.7, 3.8)2.0 (1.3, 3.1)1.8 (1.2, 2.8)
p-trend<0.001<0.0010.0020.011

eGFR, estimated glomerular filtration rate; BIS, Berlin Initiative Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin C.
Adjusted for age, race, and body mass index.
Adjusted for age, race, body mass index, hypertension, and diabetes mellitus.
Adjusted for age, race, body mass index, hypertension, diabetes mellitus, history of CHD, and self-reported health status.