Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy

Figure 7

Urinary meprin A, meprin B, nidogen-1, and monocyte chemoattractant protein-1 (MCP-1). (a) Representative immunoblots for urinary meprin A, meprin B, and nidogen-1 grouped according to diabetes status; nondiabetic controls (ND), diabetic patients with no known kidney disease (DM), and patients with diagnosed diabetic kidney disease (DKD). (b) Representative immunoblots for meprin A, meprin B, and nidogen-1 in samples from nondiabetic controls (ND) and diabetic patients without known kidney disease grouped into normo-, micro-, and macroalbuminuria based on the UACR. (c)-(d) Log-transformed plasma (c) and urinary (d) MCP-1 levels among nondiabetic controls, diabetic patients with normo-, micro-, or macroalbuminuria, and patients with diagnosed diabetic kidney disease (DKD). Urinary MCP-1 was normalized to urinary creatinine. Data are represented as mean ± SEM. Labeled means without a common letter are significantly different from one another based on one-way ANOVA and Tukey’s honest significant difference test.

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