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International Journal of Nephrology
Volume 2018, Article ID 9603453, 9 pages
https://doi.org/10.1155/2018/9603453
Research Article

Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017

1Pediatric Nephrology Division, Pediatrics Department, Fundación Cardioinfantil, Bogotá, Cundinamarca, Colombia
2Pediatric Emergency Care Division, Pediatrics Department, Fundación Cardioinfantil, Bogotá, Cundinamarca, Colombia
3Pediatric Endocrinology Division, Pediatrics Department, Fundación Cardioinfantil, Bogotá, Cundinamarca, Colombia

Correspondence should be addressed to Mayerly Prada Rico; gro.litnafnioidrac@radarpm

Received 26 February 2018; Accepted 4 June 2018; Published 28 June 2018

Academic Editor: Suresh C. Tiwari

Copyright © 2018 Mayerly Prada Rico et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Renal biopsy is the principal instrument to evaluate the diagnosis and prognosis of children with kidney disease. There are relatively few studies establishing epidemiology of its findings in the pediatric population. Methods. A descriptive study was conducted to describe characteristics of pediatric patients who had undergone a renal biopsy over the last 10 years in a national reference center, trying to accomplish an etiopathogenic approach of biopsy findings. Results. 241 patients were included. Most frequent indications were nephrotic syndrome (34.1%) and systemic disease with renal involvement (30.2%). The most prevalent biopsy diagnosis was glomerulonephritis (44%) and among these patients, glomerulonephritis mediated by immune complexes was the most frequent pathogenic type (90.5%). When the biopsy was indicated for proteinuria plus hematuria and systemic disease with renal involvement, the most frequent biopsy diagnosis was glomerulonephritis (60 and 85%, respectively). For isolated hematuria, the predominant biopsy diagnosis was inherited diseases of the glomerular basement membrane (70%) and for nephrotic syndrome, podocytopathy (82%). Glomerulonephritis was more frequent in patients older than 10 yrs (65%) and the rate of postbiopsy major complications was low (1.2%). Conclusion. Immune complex glomerulonephritis was the most frequent histological finding, differing from previous reports. To our knowledge this is the first description that classifies biopsy findings according to the probable pathogenic mechanism.