Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System

Table 2

Comparison between the current paradigm and proposed paradigm for phosphate restriction.

	Current paradigm	Proposed paradigm
Rationale	Hyperphosphatemia is a risk for vascular calcification and mortality	Increase in phosphate excretion per nephron is a risk for renal tubular damage
Goal	To lower serum phosphate levels	To lower serum FGF23 levels
Outcome	Vascular calcification, cardiovascular events, death	Renal tubular damage
Indication	Hyperphosphatemia (~0.35% of the total CKD patients)	Hyper-FGF23-emia (~8% of the total CKD patients)