International Journal of Nephrology / 2019 / Article / Tab 1

Research Article

Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease

Table 1

Characteristics of the study population.

CharacteristicsCKD Cases First-degree relativesControls p-valuep-value#
(N = 71)(N = 52)(N = 58)

Male, N (%)46 (65%)17 (33%)26 (45%)0.0230.193
Age, years48 (41-53)30 (21-50)41 (34-46)<0.0010.046
BMI, kg/m228 (24- 30)27 (25-33)28 (24-32)0.6340.853
Systolic BP, mmHg141 (132-168)129 (120-149)118 (113-130)<0.0010.002
Diastolic BP, mmHg86 (78-97)76 (72-88)73 (69-77)<0.0010.006
Serum creatinine, μmol/L769 (482-1116)76 (64-84)74 (65-83)<0.0010.853
Serum uric acid mmol/L,0.5 (0.4-0.6)0.3 (0.3- 0.3)0.3 (0.3-0.4)<0.0010.105
CKD-EPI eGFR, ml/min per 1.73 m28 (4-12)116 (91-139)121 (99-130)<0.0010.409
Urine creatinine, mgdl83 (58-120)97 (53-134)81 (57-140)0.8860.791
Uromodulin, μg/ml0.47 (0.2-3.2)2.2 (0.9- 8)2.8 (0.7- 9.5)<0.0010.866
Log Uromodulin concentration (μg/ml), mean ± SD-0.4 ±1.90.9 ± 1.21.1 ± 1.7<0.0010.524
uUMOD/uCr ratio (μg/mg)0.6 (0.2-3)3.6 (1.2-8.1)3 (1.0- 7.0)<0.0010.979
Rs13333226 genotype frequencies (AA, AG, GG), %35, 44, 2143, 35, 2240, 41,190.8680.766
Rs13333226 allele frequency (A, G), %57, 4360, 4060, 400.5920.983

Data presented as median (IQR), mean ± SD or n (%), as appropriate
-value: CKD cases vs. controls
#p-value: first-degree relatives vs. controls
P-values from Pearson’s chi square, Kruskal-Wallis, Mann-Whitney and t-test
Abbreviations: BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.