Research Article
Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease
Table 4
Relationship between rs13333226 polymorphisms in the UMOD gene and clinical and demographic features in first-degree relatives.
| | rs13333226 | AA | AG | GG | p-value# |
| | N (%) | 22 | 17 | 11 | | | Gender (M/F) | 8/14 | 6/11 | 3/8 | 0.865 | | Age, years | 34 (22-53) | 29 (20-51) | 25 (22-41) | 0.684 | | Systolic BP, mmHg | 126 (120-139) | 135 (119-149) | 128 (120-132) | 0.662 | | Diastolic BP, mmHg | 76 (72-87) | 75 (72-89) | 76 (69-82) | 0.682 | | Serum creatinine, µmol/L | 77 (64-84) | 76 (66-86) | 65 (62-92) | 0.601 | | CKD-EPI eGFR, ml/min per 1.73 m2 | 118 (82-138) | 105 (91-137) | 139 (87-143) | 0.398 | | Uric acid, mmol/L | 0.3 (0.3-0.4) | 0.3 (0.3-0.4) | 0.3 (0.2-0.3) | 0.752 | | Urine ACR mg/mmol | 1.2 (0.4-2.9) | 0.4 (0.0-2.2) | 2.9 (1.4-4.2) | 0.225 | | Log Uromodulin concentration (µg/ml), mean ±SD | 1.0 ± 1.1 | 0.8 ± 1.5 | 1.1 ± 1.0 | |
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Data given as median (interquartile range) unless specified P values- #Kruskal-Wallis unless specified; earson’s chi square; tests Abbreviations: BP, blood pressure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; ACR, albumin: creatinine ratio. |
