A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study

Table 4

Hormones during urine dilution test in patients with adult dominant polycystic kidney disease (ADPKD), patients with non-ADPKD kidney disease (non-ADPKD), and healthy control subjects controls).

		Baseline; Period 2	Period 4	Period 6	Period 7
AVP (pg/ml)	ADPKD; Non-ADPKD; Controls	0.3 ± 0.2; 0.4 ± 0.3; 0.3 ± 0.1	0.2 ± 0.1; 0.3 ± 0.2; 0.2 ± 0.1	0.3 ± 0.2; 0.3 ± 0.3; 0.3 ± 0.1	0.3 ± 0.2; 0.3 ± 0.2; 0.4 ± 0.2
Comparison within groups		0.243
Comparison between groups		0.866
PRC (pg/ml)	ADPKD; Non-ADPKD; Controls	7 [4, 9]; 8 [5, 17]; 6 [4, 8]	6 [5, 8]; 7 [5, 18]; 6 [4, 7]	7 [5, 8]; 7 [5, 19]; 5 [3, 7]	5 [4, 9]; 6 [4, 19]; 5 [3, 7]
Kruskal-Wallis test		0.136	0.297	0.059	0.550
AngII (pmol/l)	ADPKD; Non-ADPKD; Controls	6 ± 4; 5 ± 3; 5 ± 3	5 ± 3; 5 ± 3; 5 ± 4	5 ± 3; 5 ± 2; 6 ± 4	6 ± 4; 6 ± 3; 7 ± 4
Comparison within groups		0.024
Comparison between groups		0.936
Aldo (pg/ml)	ADPKD; Non-ADPKD; Controls	250 ± 115; 203 ± 147; 167 ± 49	235 ± 104; 201 ± 140; 154 ± 55	218 ± 134; 174 ± 106; 120 ± 47	238 ± 139; 170 ± 92; 136 ± 50
Comparison within groups		0.668
Comparison between groups		0.025

An oral water load of 20 ml/body weight was given immediately after period 2. Urine was collected in seven periods. Period 1 (24 hours): from 07.30 AM the day before arrival to the laboratory to 07.30 AM on the examination day. Period 2 (one hour): 07.30–08.30 AM. Period 3 (one hour): 08.30–09.30 AM. Period 4 (one hour): 09.30–11.30 AM. Period 5 (one hour): 10.30–11.30 AM. Period 6 (one hour): 11.30–00.30 PM. Period 7 (on hour): 00.30–01.30 PM. A general linear model with Greenhouse-Geisser correction was used for comparison within and between the three groups. Values represent mean ± SD or median with 25% and 75% percentiles in brackets ∗ between ADPKD or Non-ADPKD patients and controls. # between ADPKD and Non-ADPKD patients. P-AVP = plasma vasopressin, PRC = plasma renin concentration. AngII = plasma angiotensin II concentration. Aldo = plasma aldosterone concentration.