Acute Kidney Injury Caused by Obstructive Nephropathy

Figure 3

Collecting tubule changes during ON and AKI and after obstruction. (a). Collecting tubule during obstruction. (b) Collecting tubule after obstruction. In the collecting tubules during obstruction, the activity of solute transport pumps, hormonal activity, and the excretion of solutes decrease. After correction of the obstruction, it increases the excretion of free water, K, and hydrogen. Aldo, aldosterone; AMPc, adenosine monophosphate cyclic; AQP2, aquaporin 2; Ca, calcium; NaCl, sodium chloride; H₂O, water; Mg, magnesium; Na⁺, sodium; PTHr, parathormone receptor; Osm, osmolarity.