Colistin-Induced Acute Kidney Injury and the Effect on Survival in Patients with Multidrug-Resistant Gram-Negative Infections: Significance of Drug Doses Adjusted to Ideal Body Weight
Table 2
Univariate and multivariate analyses to identify the factors associated with colistin-induced AKI.
Variable
Crude HR (95% CI)
value
Adjusted HR (95% CI)
value
Age (every 1-year increase)
1.02 (1.02–1.03)
<0.001
1.02 (1.01–1.02)
<0.001
CKD (with/without)
1.87 (1.43–2.43)
<0.001
0.95 (0.65–1.39)
0.806
Vancomycin (with/without)
1.38 (1.09–1.74)
0.008
1.37 (1.08–1.75)
0.011
ACEI (with/without)
1.93 (0.91–4.11)
0.087
2.30 (1.06–4.99)
0.036
ARB (with/without)
8.56 (1.18–62.0)
0.034
7.72 (1.04–57.1)
0.045
Diuretics (with/without)
1.47 (1.14–1.89)
0.003
1.31 (1.01–1.70)
0.041
Baseline total bilirubin level (every increase of 1 mg/dL)
1.03 (1.01–1.05)
0.003
1.03 (1.01–1.06)
0.006
Septic shock (with/without)
0.77 (0.59–1.02)
0.065
1.21 (0.89–1.63)
0.224
Lactate >18 mg/dL (with/without)
1.75 (1.31–2.34)
<0.001
1.34 (0.98–1.82)
0.065
AKI before colistin administration (with/without)
2.22 (1.73–2.85)
<0.001
1.68 (1.22–2.32)
0.001
AKI with oliguria ≥2 hours before colistin administration
4.04 (2.13–7.67)
<0.001
2.91 (1.46–5.80)
0.002
Daily dose/IBW of colistin (every increase of 1 mg/kg)
0.92 (0.85–0.99)
0.037
1.12 (1.01–1.23)
0.027
Total dose/IBW of colistin (every increase of 1 mg/kg)
