Clinical Presentation, Renal Histopathological Findings, and Outcome in Patients with Monoclonal Gammopathy and Kidney Disease

Table 6

Association between monoclonal gammopathies and direct kidney injury.

Monoclonal gammopathy	Odds ratio (95% CI)^∗	value
MM	47.5 (13.7–164.9)	<0.001
NHL	2.1 (0.6–7.2)	0.194
SMM	0.5 (0.1–3)	0.5
MGUS	0.01 (0.005–0.04)	<0.001
HL	—	0.153

HL, Hodgkin lymphoma; NHL, non-Hodgkin lymphoma; MGUS, monoclonal gammopathy of indeterminate significance; MM, multiple myeloma; SMM, smoldering multiple myeloma. AL amyloidosis was not tested because the pathogenesis of amyloidosis depends on a proven direct kidney injury due to the deposition of light chain within the renal parenchyma. value for MGUS was statistically but not clinically significant. The protective effect of MGUS in developing kidney disease is not applicable in this context.